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Biomaterial strategies to replicate gynecological tissue

机译：复制妇科组织的生物材料策略

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摘要

Women's health is an important and understudied area of research. The current standard of care for many gynecological diseases such as cancer or autoimmune-linked disorders such as endometriosis is surgery; however, the underlying mechanisms of action of many gynecological diseases are poorly understood. The field of tissue engineering has the potential to transform the field of women's health by developing in vitro models of healthy and diseased tissue that could be used to identify novel treatment strategies as well as gain a better understanding of complex signaling dynamics. Identification of the appropriate biomaterials, cell types, and stimuli (the tissue engineering triad) needed to build these in vitro models can be gleaned by interrogating the underlying extracellular matrix, cell organization, and soluble factors present in the tissue. In this review, we provide a general overview of the biology and components of the major tissues that make up the female reproductive system (ovaries, fallopian tubes, the uterus, and cervix) as well as a comprehensive survey of the different biomaterials that have been chosen to build in vitro models of these tissues. Furthermore, for each tissue, we recommend guiding principles in the design of in vitro models and discuss their potential to be used in drug screening and mechanistic studies.
机译：妇女的健康是一个重要而深入的研究领域。目前对许多妇科疾病的护理标准如癌症或自身免疫关联疾病，如子宫内膜异位症是手术;然而，许多妇科疾病的潜在作用机制很差。组织工程领域具有通过开发可用于识别新颖的治疗策略的健康和患病组织的体外模型来改变女性健康领域的潜力，以便更好地了解复杂信号动态。通过询问组织中存在的潜在的细胞外基质，细胞组织和可溶性因子，可以针对构建这些体外模型所需的适当生物材料，细胞类型和刺激（组织工程三合会）的鉴定。在本综述中，我们提供了构成女性生殖系统（卵巢，输卵管，子宫和子宫颈）的主要组织的生物学和组件的一般概述以及对已有不同生物材料的综合调查选择构建这些组织的体外模型。此外，对于每个组织，我们建议在体外模型设计中引导原则，并讨论其用于药物筛选和机械研究的潜力。

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  • 来源
    《Biomaterials Science》 |2021年第4期|共18页
  • 作者

    Cadena Ines; Chen Athena; Arvidson Aaron; Fogg Kaitlin C.;

  • 作者单位

    Oregon State Univ Dept Chem Biol &

    Environm Engn Corvallis OR 97331 USA;

    Oregon Hlth &

    Sci Univ Sch Med Dept Pathol Portland OR 97201 USA;

    Oregon State Univ Dept Chem Biol &

    Environm Engn Corvallis OR 97331 USA;

    Oregon State Univ Dept Chem Biol &

    Environm Engn Corvallis OR 97331 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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