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首页> 外文期刊>Biomaterials Science >Versatile fluorinated Pd@Au nanoplates doped with yttrium for tumor theranostics
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Versatile fluorinated Pd@Au nanoplates doped with yttrium for tumor theranostics

机译：多功能氟化Pd / au纳米普板掺杂有钇的肿瘤治疗术

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摘要

As one of the emerging modalities of magnetic resonance imaging (MRI), ~(19)F MRI is highly conducive for the specific detection and imaging of deep-seated tumors, with negligible background. However, most ~(19)F MRI probe designs are constructed with organic CF3, which contains rich fluorine atoms, and few of the fluorine-containing groups are equipped with therapeutic function. Herein, we designed a versatile ~(19)F MRI-based theranostic nanoplatform, FY-Pd@Au nano-metallacages (FY-Pd@Au NCs), which not only serve as a ~(19)F MRI/CT/PAI contrast agent, but also produce reactive oxygen species (ROS) by type I photodynamic therapy (PDT) pathway, as well as heat for photothermal therapy (PTT), under the single NIR laser irradiation. Overall, this work successfully built a theranostics nanoplatform based on ~(19)F MRI.
机译：作为磁共振成像（MRI）的新出现模式之一，〜（19）F MRI对深层肿瘤的特异性检测和成像非常有利于忽略的背景。 然而，大多数〜（19）F MRI探针设计用有机CF3构建，含有富氟原子，含氟基团很少配备治疗功能。 在此，我们设计了一种多功能〜（19）F MRI的Theranostic Nanoplatform，FY-Pd @ Au纳米金属扫描（FY-PD @ Au NC），不仅用作〜（19）F MRI / CT / PAI 造影剂，但也通过I型光动力疗法（PDT）途径和热热疗法（PTT）的热量产生反应性氧物质（ROS），在单个NIR激光照射下。 总体而言，这项工作成功地构建了基于〜（19）F MRI的Theranostics Nanoplatform。

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  • 来源
    《Biomaterials Science》 |2021年第9期|共9页
  • 作者

    Hailong Jiang; Jingchao Li; Changrong Shi; Jiang Ming; Deliang Zhang; Rongqiang Zhuang; Zhide Guo; Xianzhong Zhang;

  • 作者单位

    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China;

    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China;

    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China;

    State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian Province College of Chemistry and Chemical Enginee;

    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China;

    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China;

    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China;

    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China;

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  • 正文语种 eng
  • 中图分类 计量学;
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