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首页> 外文期刊>Biomaterials Science >Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances
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Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

机译：聚合诱导的自组装（PISA）作为刺激响应药物递送系统和生物材料的直接配方策略：最近的进步

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摘要

Stimuli-responsive amphiphilic block copolymers have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, the presence of redox agents, and temperature. The formulation of amphiphilic block copolymers into polymeric drug-loaded nanoparticles is typically achieved by various methods (e.g. oil-in-water emulsion solvent evaporation, solid dispersion, microphase separation, dialysis or microfluidic separation). Despite much progress that has been made, there remain many challenges to overcome to produce reliable polymeric systems. The main drawbacks of the above methods are that they produce very low solid contents (<1 wt%) and involve multiple-step procedures, thus limiting their scope. Recently, a new self-assembly methodology, polymerisation-induced self-assembly (PISA), has shown great promise in the production of polymer-derived particles using a straightforward one-pot approach, whilst facilitating high yield, scalability, and cost-effectiveness for pharmaceutical industry protocols. We therefore focus this review primarily on the most recent studies involved in the design and preparation of PISA-generated nano-objects which are responsive to specific stimuli, thus providing insight into how PISA may become an effective formulation strategy for the preparation of precisely tailored drug delivery systems and biomaterials, while some of the current challenges and limitations are also critically discussed.
机译：刺激响应的两亲嵌段共聚物作为有前途的纳米载体，用于响应于一系列刺激，氧化还原剂和温度的刺激而增强特异性特异性和按需药物释放。将两亲嵌段共聚物的制剂通常通过各种方法（例如，水包油乳液溶剂蒸发，固体分散，微单分离，透析或微流体分离）来实现。尽管已经取得了很大的进展，但克服了许多挑战，以产生可靠的聚合物系统。上述方法的主要缺点是它们产生非常低的固体含量（<1wt％）并涉及多步骤，从而限制它们的范围。最近，一种新的自组装方法，聚合诱导的自组装（PISA），在使用直接的单盆方法的同时促进高产，可扩展性和成本效益，在生产聚合物衍生的颗粒方面已经表现出很大的希望用于制药行业协议。因此，我们主要关注这一综述，主要是关于涉及对特定刺激的比萨生成的纳米物体的设计和准备的最新研究，从而深入了解比萨如何成为准备精确定制药物的有效配方策略递送系统和生物材料，而一些当前的挑战和局限性也批判性地讨论。

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  • 来源
    《Biomaterials Science》 |2021年第1期|共13页
  • 作者

    Phan Hien; Taresco Vincenzo; Penelle Jacques; Couturaud Benoit;

  • 作者单位

    Univ Paris Est Creteil Inst Chim &

    Mat Paris Est ICMPE CNRS UMR 7182 2 Rue Henri Dunant F-94320 Thiais France;

    Univ Nottingham Sch Chem Univ Pk Nottingham NG7 2RD England;

    Univ Paris Est Creteil Inst Chim &

    Mat Paris Est ICMPE CNRS UMR 7182 2 Rue Henri Dunant F-94320 Thiais France;

    Univ Paris Est Creteil Inst Chim &

    Mat Paris Est ICMPE CNRS UMR 7182 2 Rue Henri Dunant F-94320 Thiais France;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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