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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Nucleosome movement analysis based on second-order information entropy and density functional theory
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Nucleosome movement analysis based on second-order information entropy and density functional theory

机译：基于二阶信息熵和密度函数理论的核心运动分析

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摘要

Dynamics of +1 and-1 nucleosomes near TSS of yeast chromosome 2 were analyzed by using second-order information entropy and density functional theory method. Second-order information entropy can measure the interaction intensity between nucleosome sequences and nucleosome histones based on the intensity of base association. In addition, density functional theory method can be used to obtain the global interaction intensity between nucleosome sequences and nucleosome histones based on energy state size and active or non-active state of binucleoside pairs. Our results showed asymmetry of interaction intensity on both sides of the nucleosome central site, and that +1 nucleosomes tend to move toward the 5'-end and-1 nucleosomes tend to move toward the 3'-end. Under the dynamic balance of nucleosome movement, in roder to shut down gene transcription, +1 and-1 nucleosomes will cover TSS. If the dynamic balance is destroyed, +1 and-1 nucleosomes stay away from each other to expose TSS to restart gene transcription. The movement trend of +1 and-1 nucleosomes coincides with the biological mechanism of gene transcription and non-transcription, and the nucleosome sequences contain the dynamic information of nucleosome movement, which provides effective technical support for the study of gene transcription regulation mechanism.
机译：通过使用二阶信息熵和密度泛函理论方法分析酵母染色体2的TSS附近TSS附近的+1和-1核体的动态。基于基础关联强度，二阶信息熵可以测量核体序列和核体组蛋白之间的相互作束强度。此外，密度函数理论方法可用于基于能量状态尺寸和活性或非活性或非活性或非活性或非活跃状态的核小体序列和核体组蛋白之间的全局相互作用强度。我们的结果表明，核心中心部位两侧的相互作用强度的不对称性，并且+1核体倾向于向5'-末端和1个核体移动倾向于向3'-末端移动。在核心运动的动态平衡下，在杆转录的核心转录中，+1和-1核体会覆盖TSS。如果动态平衡被破坏，+1和-1核体彼此远离，以暴露TSS以重新启动基因转录。 +1和-1核体的运动趋势与基因转录和非转录的生物机制一致，核体序列含有核心运动的动态信息，为基因转录调控机制的研究提供了有效的技术支持。

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