Evidence of cadmium and mercury involvement in the A beta 42 aggregation process

Meleleo Daniela; Sblano Cesare; Storelli Maria Maddalena; Mallamaci Rosanna

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Evidence of cadmium and mercury involvement in the A beta 42 aggregation process

机译：镉和汞涉及β22聚集过程的证据

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摘要

A beta 42 is a small peptide formed from 42 aminoacids that presents a great propensity to aggregate until it forms fibrils. A beta 42 aggregation and fibrillation are very complex processes whose molecular mechanisms seem to depend on characteristics intrinsic to the peptide molecule, as well as extrinsic factors. Peptide concentration, mean pH and several substances, including metal ions, are principal extrinsic factors for the oligomerization process. Different metals affect the aggregation of the A beta 42 molecule, and their toxicity favours the misfolding and aggregation of the peptide. In this study, we evaluate the effect of different concentrations of Cd2+ and Hg2+ on the A beta 42 peptide in solution by different methods. The toxicity of A beta 42 was evaluated with the MIT assay, while the aggregation process was monitored by single-channel measurements, electrophoresis and western blot. Cd2+ and Hg2+ seem to favour the formation of high-molecular-weight aggregates, to decrease ion channel turnover inside the membrane and to significantly increase A beta 42 toxicity.

机译：β22是由42个氨基酸形成的小肽，其呈现出具有巨大的骨料倾向，直到它形成原纤维。 β22聚集和原纤化是非常复杂的过程，其分子机制似乎取决于肽分子的特性，以及外在因子。肽浓度，平均pH和几种物质包括金属离子，是寡聚化过程的主要内在因子。不同的金属影响β22分子的聚集，并且它们的毒性有利于肽的错误折叠和聚集。在该研究中，我们通过不同方法评估不同浓度CD2 +和HG2 +对β22肽的β22肽的影响。用麻省理工学院测定评估β22的毒性，而单通道测量，电泳和Western印迹监测聚集过程。 CD2 +和Hg2 +似乎有利于形成高分子量聚集体，以减少膜内的离子通道转换并显着增加β22毒性。

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来源
《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2020年第1期|共13页
作者
Meleleo Daniela; Sblano Cesare; Storelli Maria Maddalena; Mallamaci Rosanna;
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作者单位

Univ Bari Aldo Moro Dept Biosci Biotechnol &

Biopharmaceut Via E Orabona 4 I-70126 Bari Italy;

Univ Bari Aldo Moro Dept Biosci Biotechnol &

Biopharmaceut Via E Orabona 4 I-70126 Bari Italy;

Univ Bari Aldo Moro Dept Biosci Biotechnol &

Biopharmaceut Via E Orabona 4 I-70126 Bari Italy;

Univ Bari Aldo Moro Dept Biosci Biotechnol &

Biopharmaceut Via E Orabona 4 I-70126 Bari Italy;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Cadmium; Mercury; A beta 42; Aggregation; Cytotoxicity;

机译：镉;水星;β22;聚集;细胞毒性;

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Evidence of cadmium and mercury involvement in the A beta 42 aggregation process

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