Effect of tert-alcohol functional imidazolium salts on oligomerization and fibrillization of amyloid beta (1-42) peptide

Said Madhukar S.; Navale Govinda R.; Yadav Ashok; Khonde Nilesh; Shinde Sandip S.; Jha Anjali

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Effect of tert-alcohol functional imidazolium salts on oligomerization and fibrillization of amyloid beta (1-42) peptide

机译：叔醇功能性咪唑鎓盐对淀粉样蛋白β（1-42）肽寡聚化和原纤化的影响

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Imidazolium based IL's has gained vast interest in developing biological applications. Oligomerization and fibrillization of amyloid beta (1-42) peptide are mainly responsible for the extra-neuronal deposition of amyloid fibrils in neurodegenerative disorders like Alzheimer's disease (AD). Here, we report an effect of tert-BuOH-functional imidazolium ILs on oligomerization and fibrillization of amyloid beta (1-42) Peptide in vitro. In this study, a series of these [alkyl-(t)OHim][OMs] ILs with methyl sulphonate counter anion by varying alkyl chains were used. Among the seven protic ILs, four showed strong binding and inhibition activity for the formation of amyloid beta (1-42) aggregation by using Thioflavin T fluorescence binding assay. The secondary structural analysis of the peptide, pre-incubated with active ILs shows the loss of ordered beta-sheet amyloid structure. The longer alkyl chain ILs showed that an increased in amyloid binding and hence an inhibition effect on amyloid aggregation was enhanced. Thus, we propose that ILs could be presented as potential candidates for therapeutic intervention against Alzheimer's disease (AD).

机译：基于Imidazolium的IL在开发生物学应用方面取得了巨大兴趣。淀粉样蛋白β（1-42）肽的寡聚和原纤化主要负责淀粉样蛋白原纤维的超神经元沉积，如阿尔茨海默病（AD）。这里，我们在体外报告了Tert-Buoh官能咪唑鎓ILs对淀粉样蛋白β（1-42）肽的寡聚化和原纤化的影响。在该研究中，使用通过改变烷基链的一系列具有甲磺酸甲酯对抗阴离子的[烷基 - （t）OHIM] [OMS] IL。在七种质子ILS中，通过使用硫蛋白T荧光结合测定，四个含有淀粉样蛋白β（1-42）聚集的强粘合和抑制活性。与活性ILS预孵育的肽的二次结构分析显示有序β-片状淀粉样蛋白结构的损失。较长的烷基链ILs显示淀粉样蛋白结合中的增加，因此提高了对淀粉样蛋白聚集的抑制作用。因此，我们提出了ILS可以作为针对阿尔茨海默病（AD）的治疗干预的潜在候选人。

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来源
《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2020年第1期|共7页
作者
Said Madhukar S.; Navale Govinda R.; Yadav Ashok; Khonde Nilesh; Shinde Sandip S.; Jha Anjali;
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作者单位

CSIR Natl Chem Lab Organ Chem Div Dr Homi Bhabha Rd Pune 411008 Maharashtra India;

CSIR Natl Chem Lab Organ Chem Div Dr Homi Bhabha Rd Pune 411008 Maharashtra India;

CSIR Natl Chem Lab Organ Chem Div Dr Homi Bhabha Rd Pune 411008 Maharashtra India;

CSIR Natl Chem Lab Organ Chem Div Dr Homi Bhabha Rd Pune 411008 Maharashtra India;

CSIR Natl Chem Lab Organ Chem Div Dr Homi Bhabha Rd Pune 411008 Maharashtra India;

Agharkar Res Inst Nanobiosci Grp GG Agarkar Rd Pune 411004 Maharashtra India;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Amyloid beta (1-42) peptide; Aggregation; Imidazolium ionic liquid; Biofilm inhibitor;

机译：淀粉样蛋白β（1-42）肽;聚集;咪唑鎓离子液体;生物膜抑制剂;

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2. The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity [J] . Xu Wang, Yi Yang, Mingyue Jia, 中国神经再生研究（英文版） . 2013,第001期
3. Effects of L-3-n-butylphthalide on caspase-3 and nuclear factor kappa-B expression in primary basal forebrain and hippocampal cultures after beta-amyloid peptide 1-42 treatment [J] . Ruixia Wang, Yong Zhang, Liangliang Jiang, 中国神经再生研究（英文版） . 2009,第004期
4. Islet amyloid polypeptide amyloid beta peptide roles in Alzheimer's disease: two triggers, one disease [J] . Sofia Ferreira, Ana F.Raimundo, Regina Menezes, 中国神经再生研究（英文版） . 2021,第006期
5. Nitration of amyloid-beta peptide (1-42) as a protective mechanism for the amyloid-beta peptide (1-42) against copper ion toxicity [J] . Zhao Jie, Gao Wanxia, Yang Zhen, Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2019,第期

机译：淀粉样蛋白β肽（1-42）的硝化作为淀粉样蛋白β肽（1-42）对铜离子毒性的保护机制
6. Intravenous anesthetic diazepam does not induce amyloid-beta peptide oligomerization but diazepam co-administered with halothane oligomerizes amyloid-beta peptide: an NMR study. [J] . Mandal PK, Simplaceanu V, Fodale V Journal of Alzheimer's disease: JAD . 2010,第1期

机译：一项NMR研究表明，静脉麻醉药地西epa不会诱导淀粉样β肽寡聚，但与氟烷共同使用的地西epa会使淀粉样β肽低聚。
7. Distinct oligomerization and fibrillization dynamics of amyloid core sequences of amyloid-beta and islet amyloid polypeptide [J] . Sun Yunxiang, Wang Bo, Ge Xinwei, Physical chemistry chemical physics: PCCP . 2017,第41期

机译：淀粉样蛋白β和胰岛淀粉样蛋白多肽淀粉样蛋白核心序列的明显寡聚和原纤化动力学
8. Beta-amino Acid Modified Heptapeptide Containing a Designed Recognition Element Disrupts Oligomerization and Fibrillization of the Amyloid Beta Peptide [C] . Ian W. Hamley, Valeria Castelletto PMSE Symposia . 2010

机译：含有设计识别元件的β-氨基酸改性七肽破坏了淀粉样蛋白β肽的寡聚化和原纤化
9. Amyloid beta-peptide (1-42)-mediated oxidative stress and neurotoxicity: I. The role of methionine 35. II. Proteomic identification of specifically oxidized proteins in models of Alzheimer's disease. [D] . Boyd-Kimball, Debra Lynn. 2004

机译：淀粉样β-肽（1-42）介导的氧化应激和神经毒性：I.蛋氨酸的作用35. II。蛋白质组学鉴定阿尔茨海默病模型中特定氧化的蛋白质。
10. Distinct Oligomerization and Fibrillization Dynamics of Amyloid Core Sequences of Amyloid-beta and Islet Amyloid Polypeptide [O] . Yunxiang Sun, Bo Wang, Xinwei Ge, -1

机译：β-淀粉样蛋白和胰岛淀粉样蛋白多肽的淀粉样蛋白核心序列的独特的低聚和原纤维化动力学。
11. Distinct oligomerization and fibrillization dynamics of amyloid core sequences of amyloid-beta and islet amyloid polypeptide [O] . Yunxiang Sun, Bo Wang, Xinwei Ge, 2017

机译：淀粉样蛋白β和胰岛淀粉样蛋白多肽淀粉样蛋白核心序列的明显寡聚和原纤化动力学

Effect of tert-alcohol functional imidazolium salts on oligomerization and fibrillization of amyloid beta (1-42) peptide

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