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首页> 外文期刊>Behavioural pharmacology >Repeated nicotine vapor inhalation induces behavioral sensitization in male and female C57BL/6 mice
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Repeated nicotine vapor inhalation induces behavioral sensitization in male and female C57BL/6 mice

机译：反复尼古丁蒸气吸入诱导男性和雌性C57BL / 6小鼠的行为敏化

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Electronic cigarette use has significantly increased over the past decade. However, there is limited preclinical research on the behavioral and abuse-related effects of nicotine vapor inhalation in rodents. The present study evaluates the effects of repeated nicotine vapor inhalation in male and female mice using a nicotine behavioral sensitization model. Male and female C57BL/6 mice were administered vaporized nicotine (0-10.0 mg/ml) or the positive control of intraperitoneally administered nicotine (0.5 mg/kg) once daily for 5 days, and locomotor activity was assessed. Body temperatures were measured before and after nicotine vapor inhalation to assess hypothermia. Nicotine vapor inhalation (1.0-3.0 mg/ml) produced a dose-dependent behavioral sensitization effect and produced hypothermia in male and female mice. Nicotine (0.5 mg/kg) also produced significant behavioral sensitization. No sex differences were found for nicotine behavioral sensitization with either route of administration. Pretreatment with the nonselective nicotinic antagonist mecamylamine blocked the behavioral sensitization produced by 1.0 mg/ml of nicotine vapor inhalation. These results established that nicotine vapor inhalation produces behavioral sensitization in an inverted U-shaped curve that is similar to the effects of injected nicotine across several behavioral models. Additionally, pretreatment with mecamylamine demonstrated that nicotinic receptor activation was responsible for the behavioral sensitization produced by nicotine vapor inhalation and was not a conditioned response to the vapor. The methods used in the present study provide an additional behavioral approach for evaluating the behavioral effects of repeated nicotine vapor inhalation that allows the manipulation of several variables, including e-liquid oil blend, e-liquid flavors, puff duration, etc.
机译：在过去十年中，电子烟用出显着增加。然而，有限的临床前研究啮齿动物尼古丁蒸气吸入的行为和滥用相关效果。本研究评估使用尼古丁行为敏化模型对雄性和雌性小鼠反复尼古丁蒸气吸入的影响。施用血型和雌性C57BL / 6小鼠蒸发的尼古丁（0-10.0mg / ml）或每日一次腹膜内施用的尼古丁（0.5mg / kg）阳性对照5天，并评估运动活性。在尼古丁蒸气吸入之前和之后测量体温，以评估体温过低。尼古丁蒸气吸入（1.0-3.0mg / ml）在雄性和雌性小鼠中产生了剂量依赖性的行为敏化效果并产生体温过低。尼古丁（0.5mg / kg）也产生了显着的行为敏化。没有发现尼古丁行为致敏与两种给药途径没有性差异。用非选择性烟碱拮抗剂Mecamylamine的预处理阻断了由1.0mg / ml尼古丁蒸气吸入产生的行为敏化。这些结果确定尼古丁蒸气吸入产生倒U形曲线中的行为敏化，其类似于注射尼古丁在若干行为模型中的作用。另外，含有咪酰胺的预处理证明了烟碱受体活化是由尼古丁蒸气吸入产生的行为敏化，并且不是对蒸汽的条件反应。本研究中使用的方法提供了一种用于评估重复的尼古丁蒸气吸入的行为效应的额外行为方法，其允许操纵几种变量，包括E-液体油混合物，E-液体调味剂，困难持续时间等。

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