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首页> 外文期刊>Brain imaging and behavior >Enhanced cerebro-cerebellar functional connectivity reverses cognitive impairment following electroconvulsive therapy in major depressive disorder
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Enhanced cerebro-cerebellar functional connectivity reverses cognitive impairment following electroconvulsive therapy in major depressive disorder

机译：增强的脑大脑功能连通性逆转在主要抑郁症的电静脉治疗后的认知障碍

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Electroconvulsive therapy (ECT), a rapidly acting and effective treatment for major depressive disorder (MDD), is frequently accompanied by cognitive impairment. Recent studies have documented that ECT reorganizes dysregulated inter/intra- connected cerebral networks, including the affective network, the cognitive control network(CCN) and default mode network (DMN).Moreover, cerebellum is thought to play an important role in emotion regulation and cognitive processing. However, little is known about the relationship between cerebro-cerebellar connectivity alterations following ECT and antidepressant effects or cognitive impairment. We performed seed-based resting-state functional connectivity (RSFC) analyses in 28 MDD patients receiving ECT and 20 healthy controls to identify cerebro-cerebellar connectivity differences related to MDD and changes induced by ECT. Six seed regions (three per hemisphere) in the cerebrum were selected for RSFC, corresponding to the affective network, CCN and DMN, to establish cerebro-cerebellar functional connectivity with cerebellum. MDD patients showed increased RSFC between left sgACC and left cerebellar lobule VI after ECT. Ggranger causality analyses (GCA) identified the causal interaction is from left cerebellar lobule VI to left sgACC. Furthermore, increased effective connectivity from left cerebellar lobule VI to left sgACC exhibited positively correlated with the change in verbal fluency test (VFT) score following ECT (r = 0.433, p = 0.039). Our findings indicate that the enhanced cerebro-cerebellar functional connectivity from left lobule VI to left sgACC may ameliorate cognitive impairment induced by ECT. This study identifies a potential neural pathway for mitigation of cognitive impairment following ECT.
机译：电耦合治疗（ECT），对主要抑郁症（MDD）的迅速作用和有效治疗，经常伴随着认知障碍。最近的研究已经记录了ECT重组了失去了失去的间/内联脑网络，包括情感网络，认知控制网络（CCN）和默认模式网络（DMN）.MOREBELLUM被认为在情绪调节中发挥着重要作用和认知处理。然而，关于ECT和抗抑郁效应或认知损伤之后的脑大脑连接改变之间的关系很少。我们在接受ECT和20个健康对照的28名MDD患者中进行了基于种子的静态官能连接（RSFC）分析，以确定与MDD相关的脑梗连接差异和ECT诱导的变化。为RSFC选择六个种子区域（每半球三半球），对应于情感网络，CCN和DMN，以与小脑建立脑小脑功能连通性。 MDD患者在ECT之后左侧SGACC和左脑叶VI之间的RSFC增加。 GGranger因果关系分析（GCA）确定了因果关系来自左脑叶片VI左侧SGACC。此外，从左脑叶片VI与左侧的有效连通性提高了SGACC，随着ECT的言语流畅测试（VFT）得分的变化表现出正相关（R = 0.433，P = 0.039）。我们的研究结果表明，来自左侧叶VI的增强的脑大脑功能连通性可以改善ECT诱导的认知障碍。该研究确定了潜在的神经途径，用于减轻困境后的认知障碍。

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