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首页> 外文期刊>Biochimica et Biophysica Acta. Gene Regulatory Mechanisms >The SAGA continues: The rise of cis- and trans-histone crosstalk pathways
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The SAGA continues: The rise of cis- and trans-histone crosstalk pathways

机译：SAGA继续：CIS-和TRANS-MOTYONEONEONE串衔接的兴起

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摘要

Fueled by key technological innovations during the last several decades, chromatin-based research has greatly advanced our mechanistic understanding of how genes are regulated by epigenetic factors and their associated histone-modifying activities. Most notably, the landmark finding that linked histone acetylation by Gcn5 of the Spt-Ada-Gcn5-acetyltransferase (SAGA) complex to gene activation ushered in a new area of chromatin research and a realization that histone-modifying activities have integral genome functions. This review will discuss past and recent studies that have shaped our understanding of how the histone-modifying activities of SAGA are regulated by, and modulate the outcomes of, other histone modifications during gene transcription. Because much of our understanding of SAGA was established with budding yeast, we will focus on yeast as a model. We discuss the actions of cis- and trans-histone crosstalk pathways that involve the histone acetyltransferase, deubiquitylase, and reader domains of SAGA. We conclude by considering unanswered questions about SAGA and related complexes.
机译：在过去几十年中，通过关键技术创新推动，基于染色蛋白的研究大大推进了我们对基因因表观遗传因素及其相关的组蛋白修改活动来调节基因的理解。最值得注意的是，通过SPT-ADA-GCN5-乙酰转移酶（SAGA）复合物的GCN5与基因活化的GCN5将组酮乙酰化联系在染色蛋白研究的新领域以及组蛋白改性活性具有整体基因组功能中的新领域。本综述将讨论过去和最近的研究，这些研究表明了我们对SAGA的组蛋白改性活动如何受到监管的理解，并调节基因转录期间的其他组蛋白修饰的结果。因为我们对仙人市的大部分理解是用萌芽酵母建立的，我们将专注于酵母作为模型。我们讨论CIS-和Trans-act-oderodogs串扰途径的作用，其涉及Saga的组蛋白乙酰转移酶，Deubiquitylase和Saga的读取器结构域。我们通过考虑关于SAGA和相关综合复合人的未解决问题，我们得出结论。

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