A metabolite profiling method for diagnosis of precancerous cervical lesions and HPV persistence

Walker Heather; Burrell Michael; Flatley Janet; Powers Hilary

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A metabolite profiling method for diagnosis of precancerous cervical lesions and HPV persistence

机译：一种诊断前宫颈病变和HPV持久性的代谢物分析方法

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Aim: With the advent of rapid metabolic profiling techniques and of portable mass spectrometers we examined whether cells distinguished by their cytology and persistence of human papillomavirus infection, could be easily differentiated by their metabolite profile. Materials & methods: Direct injection electrospray mass spectrometry was used in a nontargeted double-blind experiment. Samples were collected from women diagnosed with one of two grades of cervical cytology and exhibiting either human papilloma virus persistence or clearance. Cell extracts were prepared using a DNA extraction procedure and the resulting supernatant, normally discarded, was analyzed. Data were interpreted using principal component analysis. Results: The results indicate strongly that a simple metabolite profiling method could be used to rapidly identify women at increased risk of cervical cancer.

机译：目的：随着快速代谢分析技术和便携式质谱仪的出现，我们检查了通过它们的乳头瘤病毒感染的细胞学和持续性涉及的细胞是否可通过它们的代谢物概况分化。材料和方法：直接喷射电喷雾质谱法用于非靶案双盲实验。从被诊断患有两种宫颈细胞学中的一种患者的女性收集样品，并表现出人乳头瘤病毒持久性或间隙。使用DNA提取方法制备细胞提取物，并分析了所得上清液，通常丢弃。使用主成分分析来解释数据。结果：结果强烈表明，可以使用简单的代谢物分析方法来快速识别宫颈癌风险增加的妇女。

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《Bioanalysis》 |2017年第8期|共8页
作者
Walker Heather; Burrell Michael; Flatley Janet; Powers Hilary;
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作者单位

Univ Sheffield Dept Anim &

Plant Sci Western Bank Sheffield S10 2TN S Yorkshire England;

Univ Sheffield Dept Anim &

Plant Sci Western Bank Sheffield S10 2TN S Yorkshire England;

Univ Sheffield Med Sch Beech Hill Rd Sheffield S10 2RX S Yorkshire England;

Univ Sheffield Med Sch Beech Hill Rd Sheffield S10 2RX S Yorkshire England;

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原文格式 PDF
正文语种 eng
中图分类生物科学;
关键词
cervical cancer; HPV; mass spectrometry; metabolite profiling; metabolomics;

机译：宫颈癌;HPV;质谱;代谢物分析;代谢组学;

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1. Correlation of HPV infection with TLRs pathway activation and downstream gene expression in cervical precancerous lesions [J] . Bilikezi•aikemu, Wei Gong, Bahargul•ismawyil, 海南医科大学学报（英文版） . 2018,第012期
2. Correlation of HPV infection with TLRs pathway activation and downstream gene expression in cervical precancerous lesions [J] . Bilikezi?aikemu, Wei Gong, Bahargul?ismawyil, 海南医科大学学报(英文版) . 2018,第012期
3. Research of cervical cytology screening in diagnosis of 370,000 cases with cervical lesion in Guangdong [J] . Baowen Zheng, Congde Chen, Anxiang Wei, 中德临床肿瘤学杂志：英文版 . 2009,第002期
4. Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China [J] . Shuang Zhao, Xuelian Zhao, Shangying Hu, 中国癌症研究（英文版） . 2019,第004期
5. A metabolite profiling method for diagnosis of precancerous cervical lesions and HPV persistence [J] . Walker Heather, Burrell Michael, Flatley Janet, Bioanalysis . 2017,第8期

机译：一种诊断前宫颈病变和HPV持久性的代谢物分析方法
6. Detection of HPV E6/E7 mRNA in the diagnosis of cervical cancer and precancerous lesions after kidney transplantation [J] . Jing Sun, Yanna Yue, Rong Li, American Journal of Translational Research . 2021,第6期

机译：检测HPV E6 / E7 mRNA在肾移植后宫颈癌和癌前病变的诊断中
7. Correlation of HPV-DNA Test with Cytology and Histology for the Diagnosis of Cervical Cancer and Precancerous Lesions in a Tertiary Care Hospital in Bangladesh [J] . Shamina Islam, Md Nizam Uddin, Nasima Akter, Journal of Armed Forces Medical College, Bangladesh . 2017,第1期

机译：孟加拉国三级医院HPV-DNA检测与细胞学和组织学在宫颈癌和癌前病变诊断中的相关性
8. Environmental factors and HPV status predicts treatment failure of cervical precancerous lesions among Brazilian women [C] . Ilce Silva, Rosalina Kpoifman, Vanessa Dantas, Annual conference of the International Society of Exposure Science . 2014

机译：环境因素和HPV状况预测巴西女性宫颈癌前病变的治疗失败
9. Cervical precancerous lesions in HIV-positive women in Cameroon: Prevalence, predictors and potential impact of screening. [D] . Atashili, Julius. 2009

机译：喀麦隆HIV阳性妇女的宫颈癌前病变：筛查的患病率，预测因素和潜在影响。
10. Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions [O] . Li Sun, Shubin Xu, Lei Liang, -1

机译：ROC分析：HPV16 E6蛋白在早期宫颈癌及癌前病变诊断中的价值
11. A metabolite profiling method for diagnosis of precancerous cervical lesions and HPV persistence [O] . Heather Walker, Michael Burrell, Janet Flatley, 2017

机译：一种诊断前宫颈病变和HPV持久性的代谢物分析方法
12. Preliminary Experimental Results from Multi-Center Clinical Trials for Detection of Cervical Precancerous Lesions Using the Cerviscan(TM) System: A novel Full-Field Evoked Tissue Fluorescence Based Imaging Instrument. [R] . Dattamajumdar, A. K., Wells, D., Parnell, J., 2001

机译：使用Cerviscan（Tm）系统检测宫颈癌前病变的多中心临床试验的初步实验结果：一种新型全场诱发组织荧光成像仪器。

A metabolite profiling method for diagnosis of precancerous cervical lesions and HPV persistence

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