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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Intracellular pH regulation and the acid delusion
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Intracellular pH regulation and the acid delusion

机译：细胞内pH调节和酸妄想

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摘要

The hydrogen ion concentration ([H+]) in intracellular cytoplasmic fluid (ICF) must be maintained in a narrow range in all species for normal protein functions. Thus, mechanisms regulating ICF are of fundamental biological importance. Studies on the regulation of ICF [H+] have been hampered by use of pH notation, failure to consider the roles played by differences in the concentration of strong ions (strong ion difference, SID), the conservation of mass, the principle of electrical neutrality, and that [H+] and bicarbonate ions [HCO3-] are dependent variables. This argument is based on the late Peter Stewart's physical-chemical analysis of [H+] regulation reported in this journal nearly forty years ago (Stewart. 1983. Can. J. Physiol. Pharmacol. 61: 1444-1461. Doi:10.1139/y83-207). We start by outlining the principles of Stewart's analysis and then provide a general understanding of its significance for regulation of ICF [H+]. The system may initially appear complex, but it becomes evident that changes in SID dominate regulation of [H+]. The primary strong ions are Na+, K+, and Cl-, and a few organic strong anions. The second independent variable, partial pressure of carbon dioxide (PCO2), can easily be assessed. The third independent variable, the activity of intracellular weak acids ([A(tot)]), is much more complex but largely plays a modifying role. Attention to these principles will potentially provide new insights into ICF pH regulation.
机译：在所有物种中，细胞内细胞质液（ICF）中的氢离子浓度（[H+]）必须保持在一个狭窄的范围内，以实现正常的蛋白质功能。因此，调节ICF的机制具有根本的生物学意义。ICF [H+]的调节受到pH值的影响，没有考虑强离子浓度（强离子差，SID）的差异所起的作用，质量守恒，电中性的原理，以及[H+]和碳酸氢根离子[HCO3-]是因变量。这一论点基于近四十年前在该杂志上发表的已故彼得·斯图尔特对[H+]调节的物理化学分析（斯图尔特，1983年，Can.J.physical.Pharmacol.61:1444-1461.Doi:10.1139/y83-207）。我们首先概述Stewart分析的原则，然后对其对ICF[H+]监管的意义进行总体理解。该系统最初可能看起来很复杂，但很明显，SID的变化主导了[H+]的调节。初级强离子为Na+、K+和Cl-，以及少量有机强阴离子。第二个自变量是二氧化碳分压（PCO2），可以很容易地进行评估。第三个自变量，细胞内弱酸的活性（[A（tot）]）要复杂得多，但在很大程度上起着调节作用。对这些原则的关注可能会为ICF pH监管提供新的见解。

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