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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Gastroprotective effects of montelukast and Nigella sativa oil against corticosteroid- induced gastric damage: they are much more than antiasthmatic drugs
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Gastroprotective effects of montelukast and Nigella sativa oil against corticosteroid- induced gastric damage: they are much more than antiasthmatic drugs

机译：蒙特洛斯特和Nigella sativa油对皮质类固醇诱导的胃损伤的胃肠保护作用：它们远远超过抗炎药物

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摘要

Corticosteroids are used to treat a variety of diseases like bronchial asthma. However, long-term corticosteroids have a gastric ulcerogenic potential. Montelukast (MTK) and Nigella sativa oil (NSO) are used in treatment of bronchial asthma. Previous studies showed that MTK and NSO had gastroprotective effects in other models of gastric ulcer. The present study assesses synergistic gastroprotective effects of both drugs in dexamethasone (DXM)-induced gastric damage. Fifty male rats were divided into 5 groups: normal control (I), DXM group (II), MTK + DXM group (III), NSO + DXM group (IV), MTK + NSO + DXM group (V). After 7 days, stomachs were removed for biochemical analysis and histological examinations. Significant increases in malondialdehyde (MDA) level, superoxide dismutase (SOD) activity, myeloperoxidase (MPO) activity, and proliferating cell nuclear antigen (PCNA) positive cells, with significant decreases in mucus secretion were detected in DXM-treated group compared with group I. Meanwhile, significant decreases of MDA level, MPO activity, and PCNA positive cells and significant increases in mucus secretion were detected in treated groups compared with group II. SOD activity significantly decreased in group V compared with group II. We could conclude that administration of either MTK or NSO or both with DXM counteracts DXM-induced gastric lesions.
机译：皮质类固醇用于治疗多种疾病，如支气管哮喘。然而，长期使用皮质类固醇有可能导致胃溃疡。孟鲁司特（MTK）和Nigella sativa油（NSO）用于治疗支气管哮喘。之前的研究表明，MTK和NSO在其他胃溃疡模型中具有胃保护作用。本研究评估了两种药物在地塞米松（DXM）诱导的胃损伤中的协同胃保护作用。将50只雄性大鼠分为5组：正常对照组（I）、DXM组（II）、MTK+DXM组（III）、NSO+DXM组（IV）、MTK+NSO+DXM组（V）。7天后，取胃进行生化分析和组织学检查。与I组相比，DXM治疗组的丙二醛（MDA）水平、超氧化物歧化酶（SOD）活性、髓过氧化物酶（MPO）活性和增殖细胞核抗原（PCNA）阳性细胞显著增加，粘液分泌显著减少，治疗组与II组相比，PCNA阳性细胞和粘液分泌显著增加。与II组相比，V组SOD活性显著降低。我们可以得出这样的结论：MTK或NSO或两者与DXM联合应用可抵消DXM诱导的胃损伤。

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