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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Vascular function and arginine and dimethylarginines in gentamicin-induced renal failure: a possible effect of heme oxygenase 1 inducer hemin
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Vascular function and arginine and dimethylarginines in gentamicin-induced renal failure: a possible effect of heme oxygenase 1 inducer hemin

机译：常春藤蛋白诱导的肾功能衰竭中的血管功能和精氨酸和二甲基碱：血红素氧酶1诱导血红素的可能效果

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–1 ·day –1 ; i.p.) was given to rats alone or together with hemin (20 mg·kg –1 on alternate days; i.p.) for 14 days. Plasma and kidney l-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) as well as kidney 4-hydroxynonenal (HNE) levels and myeloperoxidase (MPO) activity were measured. Histopathological examinations of kidney and relaxation and contraction responses of aorta were also examined. GM increased serum SDMA, urea nitrogen (BUN), and creatinine levels and caused histopathological alterations in the kidney. GM elevated HO-1 protein and mRNA expressions, 4-HNE level, and MPO activity and decreased antioxidant enzyme activities and l-arginine levels in the kidney. Decreased relaxation and contraction were detected in the aorta. Hemin restored renal oxidative stress and inflammatory changes together with vascular dysfunction, but did not affect SDMA, BUN, or creatinine levels. We conclude that HO-1 induction may be effective in improving renal oxidative stress, inflammation, and vascular dysfunction mediated by GM.
机译：–1·天–1；i、 p.）单独或与氯化血红素（20 mg·kg-1，隔天；i.p.）一起给大鼠服用14天。测定血浆和肾脏l-精氨酸、不对称二甲基精氨酸（ADMA）和对称二甲基精氨酸（SDMA）以及肾脏4-羟基壬醛（HNE）水平和髓过氧化物酶（MPO）活性。肾组织病理学检查和主动脉的舒张和收缩反应也进行了检查。GM增加血清SDMA、尿素氮（BUN）和肌酐水平，并导致肾脏组织病理学改变。GM可提高HO-1蛋白和mRNA表达、4-HNE水平和MPO活性，并降低肾脏抗氧化酶活性和l-精氨酸水平。主动脉松弛和收缩减少。氯化血红素恢复了肾脏氧化应激和炎症变化以及血管功能障碍，但不影响SDMA、BUN或肌酐水平。我们得出结论，HO-1诱导可能在改善GM介导的肾脏氧化应激、炎症和血管功能障碍方面有效。

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