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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The effect of apelin-13 on gastric ischemia/reperfusion injury: the roles of sensory nerves and vagus nerve
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The effect of apelin-13 on gastric ischemia/reperfusion injury: the roles of sensory nerves and vagus nerve

机译：Apelin-13对胃缺血/再灌注损伤的影响：感觉神经和迷走神经的作用

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摘要

Apelin is a peptide that plays a role in physiological processes such as angiogenesis, apoptosis, and proliferation. The aim of this study was to investigate the role of capsaicin-sensitive afferent neurons and vagus in the effect of apelin against ischemia/reperfusion (I/R) injury. The experimental groups were (1) control, (2) I/R, (3) apelin + I/R, (4) vagotomy + I/R, (5) vagotomy + apelin + I/R, (6) capsaicin + I/R, (7) capsaicin + apelin + I/R, (8) lorglumide + I/R, and (9) lorglumide + apelin + I/R. To test the potential gastroprotective effect of apelin-13, apelin-13 (2 mg/kg i.v.) was administered just before both ischemia and reperfusion. A vagotomy was performed 1 week before I/R in the vagotomized groups; capsaicin (125 mg/kg s.c.) was administrated 2 weeks before I/R in the capsaicin-treated groups and lorglumide (5 mg/kg i.p.) was administered 30 min before I/R in the lorglumide-treated groups. After I/R, a variety parameters in gastric tissue were analyzed. cfos expression was determined in brainstem samples. In the I/R group, the lesion index, myeloperoxidase activity, lipid peroxidation, nitric oxide, and tumor necrosis factor-alpha increased, and mucosal blood flow, prostaglandin-E2, and calcitonin gene related peptide decreased. Apelin prevented the damaging effects of I/R and increased cfos expression in brainstem areas. Vagotomy, capsaicin, and lorglumide largely eliminated the gastroprotective effects of apelin-13. This study showed that sensory nerves and the vagus play regulatory roles in apelin-induced gastroprotection. Cholecystokinin may play a role in the effect of apelin through sensory neurons.
机译：Apelin是一种在血管生成、凋亡和增殖等生理过程中发挥作用的肽。本研究旨在探讨辣椒素敏感的传入神经元和迷走神经在阿佩林抗缺血/再灌注（I/R）损伤中的作用。实验组为（1）对照组，（2）I/R组，（3）阿佩林+I/R组，（4）迷走神经切断术+I/R组，（5）迷走神经切断术+阿佩林+I/R组，（6）辣椒素+I/R组，（7）辣椒素+阿佩林+I/R组，（8）氯葡胺+I/R组，以及（9）氯葡胺+阿佩林+I/R组。为了测试阿佩林-13的潜在胃保护作用，在缺血和再灌注前立即给予阿佩林-13（2 mg/kg I.v.）。迷走神经切断组在I/R前1周进行迷走神经切断术；辣椒素治疗组在I/R前2周给予辣椒素（125 mg/kg s.c.），而洛鲁胺治疗组在I/R前30分钟给予洛鲁胺（5 mg/kg I.p.）。I/R后，分析胃组织中的各种参数。在脑干样本中测定cfos的表达。在I/R组，病变指数、髓过氧化物酶活性、脂质过氧化、一氧化氮和肿瘤坏死因子α增加，粘膜血流量、前列腺素E2和降钙素基因相关肽减少。阿佩林可以防止I/R的破坏性作用，并增加脑干区域CFO的表达。迷走神经切断术、辣椒素和氯葡胺在很大程度上消除了apelin-13的胃保护作用。本研究表明，感觉神经和迷走神经在阿佩林诱导的胃保护中起调节作用。胆囊收缩素可能通过感觉神经元在apelin效应中发挥作用。

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