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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >C-type natriuretic peptide (CNP)/guanylate cyclase B (GC-B) system and endothelin-1(ET-1)/ET receptor A and B system in human vasculature
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C-type natriuretic peptide (CNP)/guanylate cyclase B (GC-B) system and endothelin-1(ET-1)/ET receptor A and B system in human vasculature

机译：C型Natrietic肽（CNP）/胍基环化酶B（GC-B）系统和内皮素-1（ET-1）/ ET受体A和B系统在人脉管系统中

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摘要

To assess the physiological and clinical implications of the C-type natriuretic peptide (CNP)/guanylyl cyclase B (GC-B) system in the human vasculature, we have examined gene expressions of CNP and its receptor, GC-B, in human vascular endothelial cells (ECs) and smooth muscle cells (SMCs) and have also compared the endothelin-1(ET-1)/endothelin receptor-A (ETR-A) and endothelin receptor-B (ETR-B) system in human aortic ECs (HAECs) and vascular SMCs (HSMCs) in vitro. We also examined these gene expressions in human embryonic stem (ES)/induced pluripotent stem cell (iPS)-derived ECs and mural cells (MCs). A little but significant amount of mRNA encoding CNP was detected in both human ES-derived ECs and HAECs. A substantial amount of GC-B was expressed in both ECs (iPS-derived ECs and HAECs) and SMCs (iPS-derived MCs and HSMCs). ET-1 was expressed solely in ECs. ETR-A was expressed in SMCs, while ETR-B was expressed in ECs. These results indicate the existence of a vascular CNP/GC-B system in the human vascular wall, indicating the evidence for clinical implication of the CNP/GC-B system in concert with the ET-1/ETR-A and ETR-B system in the human vasculature.
机译：为了评估C型利钠肽（CNP）/鸟苷酸环化酶B（GC-B）系统在人类血管系统中的生理和临床意义，我们检测了CNP及其受体GC-B的基因表达，并比较了内皮素-1（ET-1）/内皮素受体-A（ETR-A）和内皮素受体-B（ETR-B）系统在人主动脉内皮细胞（HAEC）和血管平滑肌细胞（HSMC）中的作用。我们还检测了这些基因在人类胚胎干细胞（ES）/诱导多能干细胞（iPS）衍生的内皮细胞和壁细胞（MC）中的表达。在人胚胎干细胞来源的内皮细胞和造血干细胞中均检测到少量但显著的编码CNP的mRNA。大量GC-B在内皮细胞（iPS衍生的内皮细胞和造血干细胞）和平滑肌细胞（iPS衍生的平滑肌细胞和造血干细胞）中表达。内皮素-1仅在内皮细胞中表达。ETR-A在平滑肌细胞中表达，而ETR-B在内皮细胞中表达。这些结果表明人类血管壁中存在血管CNP/GC-B系统，表明CNP/GC-B系统与ET-1/ETR-a和ETR-B系统在人类血管系统中的临床意义。

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