Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer

Hillis Alissandra L.; Toker Alex

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Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer

机译：乳酸点亮乳腺癌的PI3K抑制剂抗性

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Predictive biomarkers can facilitate optimal patient selection for targeted cancer therapies. In this issue of Cancer Cell, Ros et al. show the utility of noninvasive metabolic imaging of labeled carbon transfer from pyruvate to lactate to detect early response and FOXM1-mediated resistance to PI3K inhibition in estrogen-receptor-positive breast cancer.

机译：预测性生物标记物可以促进癌症靶向治疗的最佳患者选择。在本期《癌细胞》中，Ros等人展示了标记碳从丙酮酸转移到乳酸的无创代谢成像在检测雌激素受体阳性乳腺癌中的早期反应和FOXM1介导的PI3K抑制抵抗中的效用。

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《Cancer Cell》 |2020年第4期|共3页
作者
Hillis Alissandra L.; Toker Alex;
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Harvard Med Sch Beth Israel Deaconess Med Ctr Dept Pathol 330 Brookline Ave Boston MA 02215 USA;

Harvard Med Sch Beth Israel Deaconess Med Ctr Dept Pathol 330 Brookline Ave Boston MA 02215 USA;

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正文语种 eng
中图分类肿瘤学;
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1. Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells [J] . Weijia Zhang, Wei Ding, Ye Chen, 生物化学与生物物理学报：英文版 . 2011,第008期
2. STAT3 mediates resistance of CD44~＋CD24~（-/low） breast cancer stem cells to tamoxifen in vitroSTAT3 mediates resistance of CD44~＋CD24~（-/low） breast cancer stem cells to tamoxifen in vitroSTAT3 mediates resistance of CD44＋CD24（-/low） breast cancer stem cells to tamoxifen in vitro [J] . Xiaoyan Wang, Guozhu Wang, Yi Zhao, 生物医学研究杂志：英文版 . 2012,第005期
3. PI3K/Akt/mTOR inhibitors in breast cancer [J] . Joycelyn JX Lee, Kiley Loh, Yoon-Sim Yap 癌症生物学与医学：英文版 . 2015,第004期
4. PI3K/Akt/mTOR inhibitors in breast cancer [J] . Joycelyn JX Lee, Kiley Loh, Yoon-Sim Yap 癌症生物学与医学（英文版） . 2015,第004期
5. The mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating HSPB8 [J] . Jia-jie SHI, Si-meng CHEN, Chen-liang GUO, 中国药理学报：英文版 . 2018,第008期
6. A combination of the PI3K pathway inhibitor plus cell cycle pathway inhibitor to combat endocrine resistance in hormone receptor-positive breast cancer: a genomic algorithm-based treatment approach [J] . Anita Gul, Brain Leyland-Jones, Nandini Dey, American Journal of Cancer Research . 2018,第12期

机译：PI3K途径抑制剂与细胞周期途径抑制剂的组合可对抗激素受体阳性乳腺癌的内分泌抵抗：一种基于基因组算法的治疗方法
7. Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells [J] . Y Hu, R Guo, J Wei, Cell death & disease. . 2015,第12期

机译：PI3K抑制剂NVP-BKM120对克服人类乳腺癌细胞的耐药性和消除癌干细胞的作用
8. An IL6-STAT3 loop mediates resistance to PI3K inhibitors by inducing epithelial-mesenchymal transition and cancer stem cell expansion in human breast cancer cells [J] . Yang Lin, Han Siqi, Sun Yong Biochemical and Biophysical Research Communications . 2014,第3期

机译：通过在人乳腺癌细胞中诱导上皮 - 间充质转换和癌症干细胞膨胀，IL6-STAT3环路介导对PI3K抑制剂的抗性
9. Quantitative Phosphoproteomic Phenotyping of Acquired Resistance to HER2 Kinase Inhibitors in Breast Cancer using Multimodal Phosphopeptide Enrichments [C] . Erik J. Soderblom, Hongbo Gu, Jeffrey Sliva, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：使用多式磷肽富集的乳腺癌中HER2激酶抑制剂的定量磷蛋白蛋白表型
10. Overcoming Anti-Estrogen Resistance in Estrogen Receptor (ER)-Positive Breast Cancer: Rational Targeting of Phosphatidylinositol 3-Kinase (PI3K) and the Resurrection of Estrogen Therapy [D] . Hosford, Sarah 2018

机译：克服雌激素受体（ER）阳性乳腺癌中的抗雌激素抵抗：磷脂酰肌醇3-激酶（PI3K）的合理靶向和雌激素疗法的复活
11. Biomarkers of response and resistance to PI3K inhibitors in estrogen receptor-positive breast cancer patients and combination therapies involving PI3K inhibitors [O] . M Brandão, R Caparica, D Eiger, -1

机译：雌激素受体阳性乳腺癌患者对PI3K抑制剂反应和耐药的生物标志物以及涉及PI3K抑制剂的联合疗法
12. Biomarkers of response and resistance to PI3K inhibitors in estrogen receptor-positive breast cancer patients and combination therapies involving PI3K inhibitors [O] . M. Brandão, R. Caparica, D. Eiger, 2019

机译：雌激素受体阳性乳腺癌患者的响应和抗PI3K抑制剂的生物标志物及涉及PI3K抑制剂的组合疗法
13. Activation of PI3K/PKB Signaling in Breast Cancer May Inhibit TGF-Beta- Induced G1 Arrest Through Changes in p27 Function [R] . Liang, J. , Slingerland, J. M. 2002

机译：乳腺癌中pI3K / pKB信号的激活可通过p27功能的变化抑制TGF-β诱导的G1期逮捕

Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer

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