Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

Wu Sihan; Mischel Paul S.

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Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

机译：相同的脚本，不同的演员：不同的细胞来源形状的形状分子特征和胶质母细胞的治疗反应

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Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.

机译：根据转录组学分类，胶质母细胞瘤在分子亚型上具有异质性。在本期《癌症细胞》中，Wang等人定义了一个基于细胞谱系的胶质母细胞瘤分层模型，强调了起源细胞如何通过相同的驱动突变产生不同的分子景观和治疗脆弱性。

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《Cancer Cell》 |2020年第3期|共4页
作者
Wu Sihan; Mischel Paul S.;
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作者单位

Univ Calif San Diego Dept Cellular &

Mol Med La Jolla CA 92093 USA;

Univ Calif San Diego Dept Cellular &

Mol Med La Jolla CA 92093 USA;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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1. Blastic Plasmacytoid Dendritic Cell Neoplasm:Progress in Cell Origin,Molecular Biology,Diagnostic Criteria and Therapeutic Approaches [J] . Wei CHENG, Tian-tian YU, Ai-ping TANG, 当代医学科学(英文) . 2021,第003期
2. Glioblastoma stem cells and Wnt signaling pathway: molecular mechanisms and therapeutic targets [J] . Ruoyu Guan, Xiaoming Zhang, Mian Guo 中华神经外科杂志（英文） . 2020,第004期
3. Glioblastoma stem cells and Wnt signaling pathway:molecular mechanisms and therapeutic targets [J] . Ruoyu Guan, Xiaoming Zhang, Mian Guo 中华神经外科杂志（英文） . 2020,第004期
4. Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: Implications for the anti-tumor barrier concept and treatment [J] . Jirina Bartkova, Christina E. Hoei-Hansen, Katerina Krizova, Molecular oncology. . 2014,第8期

机译：颅内生殖细胞肿瘤与胶质母细胞瘤中DNA损伤反应的模式反映了起源细胞而不是脑环境：抗肿瘤屏障概念和治疗的含义
5. Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. [J] . Lai A, Kharbanda S, Pope WB, Journal of Clinical Oncology . 2011,第34期

机译：来自不同来源的IDH1突变胶质母细胞瘤的分子进化的测序证据。
6. The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin [J] . Derek Van Der Kooy, Tania O. Alexson, Tamara Holowacz, Biology Open . 2013,第8期

机译：神经干细胞对GSK-3水平的反应取决于起源组织神经干细胞对GSK-3水平的反应取决于起源组织神经干细胞对GSK-3水平的反应3取决于起源的组织
7. Radiogenomics of glioblastoma: a pilot multi-institutional study to investigate a relationship between tumor shape features and tumor molecular subtype [C] . Nicholas M. Czarnek, Kal Clark, Katherine B. Peters, Conference on medical imaging . 2016

机译：胶质母细胞瘤的放射基因组学：一项多机构研究，旨在研究肿瘤形状特征与肿瘤分子亚型之间的关系
8. The Assessment of Glioblastoma Tumorspheres Reveals Molecular Determinants of Proliferation and Therapeutic Response [D] . Laks, Dan RIchard 2015

机译：胶质母细胞瘤肿瘤球的评估揭示了增殖和治疗反应的分子决定因素。
9. CSIG-06. THE MOLECULAR SUBTYPE OF PRIMARY GLIOBLASTOMA CELLS CORRELATES WITH RESPONSE TO THERAPEUTIC AGENTS THAT INDUCE APOPTOSIS OR SENESCENCE [O] . Ritesh Kumar, Ian Lorimer -1

机译：CSIG-06。原发性胶质母细胞细胞的分子亚型与诱导凋亡或衰老的治疗剂相关。
10. CSIG-06. THE MOLECULAR SUBTYPE OF PRIMARY GLIOBLASTOMA CELLS CORRELATES WITH RESPONSE TO THERAPEUTIC AGENTS THAT INDUCE APOPTOSIS OR SENESCENCE [O] . Ritesh Kumar, Ian Lorimer 2018

机译：CSIG-06。原发性胶质母细胞瘤细胞的分子亚型与对诱导细胞凋亡或衰老的治疗剂的反应相关
11. Targeting the Immune System's Natural Response to Cell Death to Improve Therapeutic Response in Breast Cancers. [R] . Cook, R. S. 2016

机译：针对免疫系统对细胞死亡的自然反应，以改善乳腺癌的治疗反应。

Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

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