Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

Schmidt Keith T.; Huitema Alwin D. R.; Dorlo Thomas P. C.; Peer Cody J.; Cordes Lisa M.; Sciuto Linda; Wroblewski Susan; Pommier Yves; Madan Ravi A.; Thomas Anish; Figg William D.

首页> 外文期刊>Cancer chemotherapy and pharmacology. >Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

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Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

机译：高级实体肿瘤施用NLG207后纳米粒子结合和游离喜树碱的人口药代动力学分析

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Purpose NLG207 (formerly CRLX101) is a nanoparticle-drug conjugate (NDC) of the potent topoisomerase I inhibitor, camptothecin (CPT). The present study sought to characterize the complex pharmacokinetics (PK) of NLG207 and better describe CPT release from nanoparticles using a population PK (popPK) model.

机译：目的NLG207（原名CRLX101）是一种有效的拓扑异构酶I抑制剂喜树碱（CPT）的纳米药物结合物（NDC）。本研究试图描述NLG207的复杂药代动力学（PK），并使用群体PK（popPK）模型更好地描述纳米颗粒释放的CPT。

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《Cancer chemotherapy and pharmacology.》 |2020年第4期|共12页
作者
Schmidt Keith T.; Huitema Alwin D. R.; Dorlo Thomas P. C.; Peer Cody J.; Cordes Lisa M.; Sciuto Linda; Wroblewski Susan; Pommier Yves; Madan Ravi A.; Thomas Anish; Figg William D.;
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作者单位

NCI Clin Pharmacol Program Ctr Canc Res NIH 9000 Rockville Pike Bldg 10 Room 5A03 Bethesda MD;

Netherlands Canc Inst Dept Pharm &

Pharmacol Amsterdam Netherlands;

Netherlands Canc Inst Dept Pharm &

Pharmacol Amsterdam Netherlands;

NCI Clin Pharmacol Program Ctr Canc Res NIH 9000 Rockville Pike Bldg 10 Room 5A03 Bethesda MD;

NCI Genitourinary Malignancies Branch Ctr Canc Res NIH Bethesda MD 20892 USA;

NCI Dev Therapeut Branch Ctr Canc Res NIH Bethesda MD 20892 USA;

NCI Genitourinary Malignancies Branch Ctr Canc Res NIH Bethesda MD 20892 USA;

NCI Dev Therapeut Branch Ctr Canc Res NIH Bethesda MD 20892 USA;

NCI Genitourinary Malignancies Branch Ctr Canc Res NIH Bethesda MD 20892 USA;

NCI Dev Therapeut Branch Ctr Canc Res NIH Bethesda MD 20892 USA;

NCI Clin Pharmacol Program Ctr Canc Res NIH 9000 Rockville Pike Bldg 10 Room 5A03 Bethesda MD;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Nanoparticle; Drug release; Population pharmacokinetics; Topoisomerase I; NLMEM;

机译：纳米粒子;药物释放;人口药代动力学;Topoisomerase I;NLMEM;

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9. Clinical pharmacology of camptothecins: Model based population pharmacokinetic and pharmacodynamic analysis. [D] . Klein, Cheri Enders. 2002

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11. Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors [O] . Keith T. Schmidt, Alwin D. R. Huitema, Thomas P. C. Dorlo, 2020

机译：纳米粒子结合的人口药代动力学分析和先进实体瘤的成人NLG207
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Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

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