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首页> 外文期刊>Cardiovascular and Interventional Radiology: A Journal of Imaging in Diagnosis and Treatment >Successful Revascularization has a Significant Impact on Limb Salvage Rate and Wound Healing for Patients with Diabetic Foot Ulcers: Single-Centre Retrospective Analysis with a Multidisciplinary Approach
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Successful Revascularization has a Significant Impact on Limb Salvage Rate and Wound Healing for Patients with Diabetic Foot Ulcers: Single-Centre Retrospective Analysis with a Multidisciplinary Approach

机译：成功的血运重建对糖尿病足溃疡患者的肢体救生率和伤口愈合产生重大影响：单中心回顾性分析，具有多学科方法

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Purpose Analyze the impact of endovascular revascularization on major amputation rates and wound healing for patients with diabetic foot ulcers (DFUs). Materials and Methods Single-center retrospective study from 2014-2018 including 314 patients with DFUs submitted to endovascular revascularizations. Group A-patients with a successful endovascular revascularization (n = 285; 90.8%); Group B-patients submitted to a failed attempt of endovascular revascularization (n = 29; 9.2%). Baseline data were not significantly different between the 2 groups (p > 0.05). Both groups were compared regarding: major amputation rates; wound healing, mortality and adverse events. Survival and regression analyses were used. Results Mean follow-up time was 734.1 +/- 610.2 days. Major amputation rates were 3.9% versus 24.1% (p < 0.0001) and complete wound healing was 53.7% versus 20.7% (p < 0.0001) for patients from Group A versus Group B, respectively. Major adverse events were registered in 2 patients (one from each group); minor adverse events included 10 patients from Group A and 2 patients from Group B (p = 0.3654). Major amputation rates were: 3.9% versus 27.5% at 1 year; 4.6% versus 27.5% at 2-5 years for Group A versus Group B, respectively (p < 0.0001). Survival rates were: 87.8% at 1 year; 84.4% at 2 years; and 77.9% at 5 years with no significant differences between groups. Predictors for major amputation included failed revascularization (p < 0.0001), older age (p = 0.0394), prior stroke (0.0018), dialysis (0.0476). Predictors for mortality included older age (p < 0.0001) and coronary artery disease (p = 0.0388). Conclusion Endovascular revascularization for patients with DFUs is safe and has a significant impact on limb salvage and wound healing.
机译：目的分析血管内血运重建对糖尿病足溃疡（DFUs）患者主要截肢率和伤口愈合的影响。材料和方法2014-2018年的单中心回顾性研究，包括314例接受血管内血运重建的DFUs患者。A组：血管内血运重建成功的患者（n=285；90.8%）；B组患者接受血管内血运重建失败（n=29；9.2%）。两组之间的基线数据没有显著差异（p>0.05）。对两组患者的主要截肢率进行比较；伤口愈合、死亡率和不良事件。采用生存率和回归分析。结果平均随访时间为734.1+/-610.2天。A组和B组的主要截肢率分别为3.9%和24.1%（p<0.0001），伤口完全愈合率分别为53.7%和20.7%（p<0.0001）。两名患者（每组一名）记录了重大不良事件；轻微不良事件包括A组10名患者和B组2名患者（p=0.3654）。主要截肢率分别为：3.9%和1年时的27.5%；A组和B组在2-5年时分别为4.6%和27.5%（p<0.0001）。1年生存率为87.8%；2年时为84.4%；5年时为77.9%，组间无显著差异。主要截肢的预测因素包括血运重建失败（p<0.0001）、高龄（p=0.0394）、既往卒中（0.0018）、透析（0.0476）。死亡率的预测因素包括高龄（p<0.0001）和冠心病（p=0.0388）。结论DFUs患者血管内血运重建是安全的，对保肢和伤口愈合有重要影响。

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