OPCs on a Diet: A Youthful Serving of Remyelination

Charles W. White III; Karishma Pratt; Saul A. Villeda

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OPCs on a Diet: A Youthful Serving of Remyelination

机译：opcs节食：年轻的remyelination服务

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Remyelination declines in the aging central nervous system due to oligodendrocyte precursor cell (OPC) dysfunction. In the latest issue of Cell Stem Cell, Neumann et al. (2019) demonstrate that aged OPCs are amenable to functional rejuvenation by systemic interventions involving alternate-day fasting or treatment with the fasting mimetic metformin.

机译：由于少突胶质细胞前体细胞（OPC）功能障碍，衰老中枢神经系统的再髓鞘化下降。在最新一期的《细胞干细胞》（Cell Stem Cell）中，Neumann et al.（2019）证明，老年OPC可以通过系统性干预（包括隔日禁食或用禁食模拟二甲双胍治疗）恢复功能。

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《Cell metabolism》 |2019年第6期|共3页
作者
Charles W. White III; Karishma Pratt; Saul A. Villeda;
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Department of Anatomy University of California San Francisco San Francisco CA USA;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. Youthful Vitality [J] . Yan Wei 北京周报：英文版 . 2021,第022期
2. Grey matter OPCs are less mature and less sensitive to IFNγ than white matter OPCs: consequences for remyelination [J] . Dennis H. Lentferink, Jacomien M. Jongsma, Inge Werkman, Scientific reports. . 2018,第1期

机译：与白质OPC相比，灰质OPC不那么成熟，对IFNγ的敏感性更低：髓鞘再生的后果
3. Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models [J] . BoydA., ZhangH., WilliamsA. Acta Neuropathologica . 2013,第6期

机译：OPC迁移到脱髓鞘病变中的不足是MS和小鼠模型中髓鞘再生不良的原因
4. Neural repair and rehabilitation: Fibroblast-derived OPCs - Hope for remyelination therapy? [J] . MalpassK. Nature reviews. Neurology . 2013,第6期

机译：神经修复和康复：成纤维细胞衍生的OPC-希望进行髓鞘再生治疗吗？
5. MATHEMATICAL MODELLING OF REMYELINATION: ASTROCYTES AS MOVING BOUNDARY CONDITIONS [C] . Saber Dini, Fariba Bahrami IASTED international conference on Biomedical Engineering . 2013

机译：再脱蛋白的数学建模：运动边界条件的星形胶质细胞
6. Targeting the Disialoganglioside GD2 with Chimeric Antigen Receptor T Cells for Immunotherapy in Diffuse Midline Gliomas, and Exploration of Neuron-OPC Synaptic Connectivity in the Context of Adaptive Myelination [D] . Mount, Christopher W. 2020

机译：用嵌合抗原受体T细胞靶向Diaialoganglioside GD2，用于在弥漫性中线胶质瘤中的免疫疗法，以及在适应性髓鞘中的背景下探索神经元-Popaptic连通性
7. Grey matter OPCs are less mature and less sensitive to IFNγ than white matter OPCs: consequences for remyelination [O] . Dennis H. Lentferink, Jacomien M. Jongsma, Inge Werkman, -1

机译：与白质OPC相比灰质OPC不那么成熟对IFNγ的敏感性更低：髓鞘再生的后果
8. OPCs on a Diet: A Youthful Serving of Remyelination [O] . Charles W. White, Karishma Pratt, Saul A. Villeda 2019

机译：opcs节食：年轻的remyelination服务
9. Rise of Marijuana as the Drug of Choice Among Youthful Adult Arrestees. Researchin Brief [R] . Golub, A., Johnson, B. D. 2001

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OPCs on a Diet: A Youthful Serving of Remyelination

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