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首页> 外文期刊>Caries research >Demineralization Inhibitory Effects of Highly Concentrated Fluoride Dentifrice and Fluoride Gels/Solutions on Sound Dentin and Artificial Dentin Caries Lesions in vitro
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Demineralization Inhibitory Effects of Highly Concentrated Fluoride Dentifrice and Fluoride Gels/Solutions on Sound Dentin and Artificial Dentin Caries Lesions in vitro

机译：高度浓缩氟化氟胺和氟化物凝胶/溶液对牙本质和人工牙本质龋病的脱矿抑制作用

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Objectives: The aim of this in vitro study was to compare the demineralization inhibitory effect of gels/solutions used in combination with either standard or highly fluoridated dentifrices on sound dentin as well as on artificial dentin caries-like lesions. Methods: Bovine dentin specimens (n = 240) with two different surfaces each (sound [ST] and artificial caries lesion [DT]) were prepared and randomly allocated to twelve groups. Weekly interventions during pH-cycling (28 days, 6 x 120 min demineralization/day) were: the application of gels/solutions containing amine fluoride/sodium fluoride (12,500 ppm F [ppm]; pH = 4.4; AmF); NaF (12,500 ppm; pH = 6.6; NaF1); NaF (12,500 ppm; pH = 6.3; NaF2); silver diamine fluoride (14,200 ppm; pH = 8.7; SDF); acidulated phosphate fluoride (12,500 ppm; pH = 3.8; APF), and no intervention (standard control; S). Furthermore, half of the specimens in each group were brushed (10 s; twice per day) with dentifrice slurries containing either 1,450 ppm (e.g., AmF1450) or 5,000 ppm (e.g., AmF5000). Differences in integrated mineral loss (Delta Delta Z) and lesion depth (Delta LD) were calculated between values before and after pH-cycling using transversal microradiography. Results: After pH-cycling Ss showed significantly increased Delta Z(DT) and LDDT values, indicating further demineralization. In contrast, except for one, all groups including fluoride gels/solutions showed significantly decreased Delta Z(DT) values. Additional use of most fluoride gels/solutions significantly enhanced mineral gain, mainly in the surface area; however, acidic gels/solutions seemed to have negative effects on lesion depths. Significance: Under the present pH-cycling conditions the highly fluoridated dentifrice significantly reduced caries progression and additional application of nearly all of the fluoride gels/solutions resulted in remineralization. However, there was no difference in the remineralizing capacity of fluoride gels/solutions when used in combination with either standard or highly fluoridated dentifrices.
机译：目的：本体外研究的目的是比较凝胶/溶液与标准或高氟牙膏联合使用对健康牙本质和人工牙本质龋齿样病变的脱矿抑制效果。方法：制备两种不同表面的牛牙本质标本（n=240）并随机分为12组。pH循环期间的每周干预措施（28天，6 x 120分钟脱矿/天）为：使用含有胺氟化物/氟化钠（12500 ppm F[ppm]；pH=4.4；AmF）的凝胶/溶液；氟化钠（12500 ppm；pH=6.6；氟化钠1）；氟化钠（12500 ppm；pH=6.3；氟化钠）；氟化银二胺（14200 ppm；pH=8.7；SDF）；酸化磷酸氟（12500 ppm；pH=3.8；APF），无干预（标准对照；S）。此外，每组有一半的样本用含有1450 ppm（例如AmF1450）或5000 ppm（例如AmF5000）的牙膏浆刷洗（10秒；每天两次）。使用横向显微摄影术计算pH循环前后的综合矿物质损失（δZ）和病变深度（δLD）的差异。结果：pH循环后，Ss显示δZ（DT）和LDDT值显著增加，表明进一步脱矿。相比之下，除一组外，包括氟化物凝胶/溶液在内的所有组的δZ（DT）值均显著降低。大多数氟化物凝胶/溶液的额外使用显著增加了矿物质的增加，主要是在表面积；然而，酸性凝胶/溶液似乎对病变深度有负面影响。重要意义：在目前的pH循环条件下，高氟牙膏显著减少龋齿的发展，并且几乎所有氟凝胶/溶液的额外应用导致再矿化。然而，与标准或高氟牙膏结合使用时，氟化物凝胶/溶液的再矿化能力没有差异。

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