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首页> 外文期刊>Cell biology international. >Experimental models of maternal–fetal interface and their potential use for nanotechnology applications
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Experimental models of maternal–fetal interface and their potential use for nanotechnology applications

机译：母胎界面的实验模型及其用于纳米技术应用的潜在用途

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Abstract During pregnancy, the placenta regulates the transfer of oxygen, nutrients, and residual products between the maternal and fetal bloodstreams and is a key determinant of fetal exposure to xenobiotics from the mother. To study the disposition of substances through the placenta, various experimental models are used, especially the perfused placenta, placental villi explants, and cell lineage?models. In this context, nanotechnology, an area of study that is on the rise, enables the creation of particles on nanometric scales capable of releasing drugs aimed at specific tissues. An important reason for furthering the studies on transplacental transfer is to explore the potential of nanoparticles (NPs), in new delivery strategies for drugs that are specifically aimed at the mother, the placenta, or the fetus and that involve less toxicity. Due to the fact that the placental barrier is essential for the interaction between the maternal and fetal organisms?as well as the possibility of NPs being used in the treatment of various pathologies, the aim of this review is to present the main experimental models used in studying the maternal–fetal interaction and the action of NPs in the placental environment.
机译：摘要在妊娠期间，胎盘调节母体和胎儿血流之间氧气、营养素和残余产物的转移，是胎儿接触母体外源性物质的关键决定因素。为了研究物质通过胎盘的分布，使用了各种实验模型，尤其是灌注胎盘、胎盘绒毛外植体和细胞谱系？模型。在这种情况下，纳米技术这一正在兴起的研究领域能够在纳米尺度上创造出能够释放针对特定组织的药物的粒子。进一步研究胎盘转移的一个重要原因是探索纳米颗粒（NPs）在新的药物递送策略中的潜力，这些药物专门针对母亲、胎盘或胎儿，毒性较小。因为胎盘屏障对于母体和胎儿有机体之间的相互作用至关重要？除了纳米粒用于治疗各种疾病的可能性外，本综述的目的是介绍用于研究母体-胎儿相互作用和纳米粒在胎盘环境中的作用的主要实验模型。

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