Folium Sennae and emodin reverse airway smooth muscle contraction

Qiu Jun-Ying; Ma Li-Qun; Liu Bei-Bei; Zhang Wen-Jing; Liu Meng-Su; Wang Ge-Ge; Zhao Xiao-Xue; Luo Xi; Wang Qian; Xu Hao; Zang Dun-An; Shen Jinhua; Peng Yong-Bo; Zhao Ping; Xue Lu; Yu Meng-Fei; Chen Weiwei; Dai Jiapei; Liu Qing-Hua

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Folium Sennae and emodin reverse airway smooth muscle contraction

机译：Folium sennae和大黄型反向气道平滑肌收缩

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The objective of this project was to find a bronchodilatory compound from herbs and clarify the mechanism. We found that the ethanol extract of Folium Sennae (EEFS) can relax airway smooth muscle (ASM). EEFS inhibited ASM contraction, induced by acetylcholine, in mouse tracheal rings and lung slices. High-performance liquid chromatography assay showed that EEFS contained emodin. Emodin had a similar reversal action. Acetylcholine-evoked contraction was also partially reduced by nifedipine (a selective inhibitor of L-type voltage-dependent Ca2+ channels, LVDCCs), YM-58483 (a selective inhibitor of store-operated Ca2+ entry, SOCE), as well as Y-27632 (an inhibitor of Rho-associated protein kinase). In addition, LVDCC- and SOCE-mediated currents and cytosolic Ca2+ elevations were inhibited by emodin. Emodin reversed acetylcholine-caused increases in phosphorylation of myosin phosphatase target subunit 1. Furthermore, emodin, in vivo, inhibited acetylcholine-induced respiratory system resistance in mice. These results indicate that EEFS-induced relaxation results from emodin inhibiting LVDCC, SOCE, and Ca2+ sensitization. These findings suggest that Folium Sennae and emodin may be new sources of bronchodilators.

机译：本项目的目的是从草药中找到一种支气管扩张化合物，并阐明其作用机制。我们发现番泻叶乙醇提取物（EEFS）可以放松气道平滑肌（ASM）。EEFS抑制乙酰胆碱诱导的小鼠气管环和肺切片的ASM收缩。高效液相色谱分析表明EEF中含有大黄素。大黄素也有类似的逆转作用。硝苯地平（L型电压依赖性钙通道的选择性抑制剂，LVDCs）、YM-58483（存储操作性钙通道的选择性抑制剂，SOCE）以及Y-27632（Rho相关蛋白激酶的抑制剂）也能部分减少乙酰胆碱诱发的收缩。此外，大黄素抑制LVDCC和SOCE介导的电流和胞浆Ca2+升高。大黄素逆转乙酰胆碱引起肌球蛋白磷酸酶靶亚单位1磷酸化增加。此外，大黄素在体内抑制乙酰胆碱诱导的小鼠呼吸系统抵抗。这些结果表明，EEFS诱导的舒张是大黄素抑制LVDCC、SOCE和Ca2+致敏的结果。这些发现表明番泻叶和大黄素可能是支气管扩张剂的新来源。

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《Cell biology international.》 |2020年第9期|共11页
作者
Qiu Jun-Ying; Ma Li-Qun; Liu Bei-Bei; Zhang Wen-Jing; Liu Meng-Su; Wang Ge-Ge; Zhao Xiao-Xue; Luo Xi; Wang Qian; Xu Hao; Zang Dun-An; Shen Jinhua; Peng Yong-Bo; Zhao Ping; Xue Lu; Yu Meng-Fei; Chen Weiwei; Dai Jiapei; Liu Qing-Hua;
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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Ca2+ sensitization; emodin; Folium Sennae; L-type voltage-dependent Ca2+ channels; respiratory system resistance; store-operated Ca2+ entry;

机译：CA2 +敏化;大蛋白;叶片;L型电压依赖性CA2 +通道;呼吸系统抵抗;存储操作CA2 +进入;

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2. Potassium channels in airway smooth muscle and airway hyperreactivity in asthma [J] . LIU Xian-sheng, XU Yong-jian 中华医学杂志（英文版） . 2005,第007期
3. NS8593 inhibits Ca2+ permeant channels reversing mouse airway smooth muscle contraction [J] . Liu Bei-Bei, Peng Yong-Bo, Zhang Wen-Jing, Life sciences . 2019,第1期

机译：NS8593禁止CA2 + Permeant通道逆转小鼠气道平滑肌收缩
4. Reverse-mode NCX current in mouse airway smooth muscle: Na + and voltage dependence, contributions to Ca 2+ influx and contraction, and altered expression in a model of allergen-induced hyperresponsiveness [J] . RahmanM., InmanM., KissL., Acta physiologica . 2012,第2期

机译：小鼠气道平滑肌的反向模式NCX电流：Na +和电压依赖性，对Ca 2+内流和收缩的贡献以及在变应原诱导的高反应性模型中表达的改变
5. Effect of antioxidants on airway smooth muscle contraction: action of lipoic acid and some of its novel derivatives on guinea pig tracheal smooth muscle [J] . E. S. K. Assem, S. Mann, B. Y. C. Wan, Inflammation Research . 2010,第s2期

机译：抗氧化剂对气道平滑肌收缩的影响：硫辛酸及其一些新衍生物对豚鼠气管平滑肌的作用
6. Airway Smooth Muscle Modulates Airway Inflammation in Asthma [C] . Wu Guoxin, rnXu Xiaoli, rnLiu Qiushuang Journal of Organ Dysfunction: ISRD 2007 Abstract Book . 2007

机译：气道平滑肌调节哮喘的气道炎症
7. Airway wall deformation under smooth muscle contraction. [D] . Javier, Carlos. 2016

机译：平滑肌收缩下气道壁变形。
8. Signal pathways involved in emodin-induced contraction of smooth muscle cells from rat colon [O] . Tao Ma, Qing-Hui Qi, Jian Xu, 2004

机译：大黄素诱导大鼠结肠平滑肌细胞收缩的信号途径
9. Transforming growth factor-β enhances Rho-kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1:TGF-β, ARHGEF1 and Rho-kinase in airway smooth muscle [O] . Shaifta, Yasin Mohammad, MacKay, Charles Edward, Irechukwu, Nneka Ifeoma, 2017

机译：转化生长因子-β通过核苷酸交换因子ARHGEF1：TGF-β，ARHGEF1和Rho激酶在气道平滑肌中增强Rho激酶活性和气道平滑肌收缩
10. Relaxation of Soman-Induced Contracture of Airway Smooth Muscle in vitro [R] . Filbert, M. G., Moore, D. H., Adler, M. 1992

机译：soman诱导气道平滑肌挛缩的体外松弛

Folium Sennae and emodin reverse airway smooth muscle contraction

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