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首页> 外文期刊>Cell and Tissue Research >MicroRNAs in Sertoli cells: implications for spermatogenesis and fertility
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MicroRNAs in Sertoli cells: implications for spermatogenesis and fertility

机译：Sertoli细胞中的Micrornas：对精子发生和生育的影响

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In recent decades, infertility has been considered a major widespread public health issue of very high concern. Currently, almost 50% of infertility cases are due to male factors, including semen disorders, obstructions, cryptorchidism, varicocele and testicular failures, which can occur due to malfunctions in both somatic and germ cells. In this context, besides other approaches, different miRNAs have been used as biomarkers for the diagnosis of male infertility, with different pathologic conditions such as Sertoli cell-only syndrome, mixed atrophy, and germ cell arrest. However, most studies related to male fertility do not point out the functions and cell targets of the described miRNAs. Initial investigations using experimental assays in murine and porcine models were performed, providing the first evidence of the influence of miRNAs on Sertoli cell function including, for instance, proliferation, maturation and hormone responses of these cells. The aim of this mini-review is therefore to summarize our present knowledge of this relevant subject and to highlight the importance of future investigations concerning the miRNA influence in the control of Sertoli cells, spermatogenesis and male fertility.
机译：近几十年来，不孕症一直被认为是一个广泛关注的重大公共卫生问题。目前，近50%的不孕症病例是由男性因素引起的，包括精液障碍、梗阻、隐睾、精索静脉曲张和睾丸衰竭，这些都可能是由于体细胞和生殖细胞的功能失调引起的。在这种情况下，除了其他方法外，不同的miRNA被用作诊断男性不育的生物标记物，具有不同的病理条件，如仅支持细胞综合征、混合性萎缩和生殖细胞停滞。然而，大多数与男性生育有关的研究并没有指出所述miRNA的功能和细胞靶点。在小鼠和猪模型中使用实验分析进行了初步研究，首次证明了miRNA对支持细胞功能的影响，包括这些细胞的增殖、成熟和激素反应。因此，这篇小型综述的目的是总结我们目前对这一相关主题的认识，并强调未来研究miRNA对支持细胞、精子发生和男性生育能力控制的重要性。

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