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首页> 外文期刊>Cell and Tissue Research >NCAPG2 facilitates glioblastoma cells' malignancy and xenograft tumor growth via HBO1 activation by phosphorylation
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NCAPG2 facilitates glioblastoma cells' malignancy and xenograft tumor growth via HBO1 activation by phosphorylation

机译：NCAPG2通过HBO 1通过磷酸化促进胶质母细胞瘤细胞的恶性肿瘤和异种移植肿瘤生长

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摘要

NCAPG2 (non-SMC condensin II complex subunit G2), as an important factor in cell mitosis, has been the focus in the study of different cancers. However, the role of NCAPG2 in the malignancy of glioblastoma cells remains unknown. The findings from the present study demonstrated that NCAPG2 was significantly increased in human glioblastoma tissues and was associated with poor clinical outcome. Moreover, NCAPG2 could promote proliferation, migration, and invasion and regulate cell cycle in glioblastoma cells. Investigation of the molecular mechanism indicated that NCAPG2 regulated HBO1 phosphorylation and H4 histone acetylase activation, modulated the activation of Wnt/beta-catenin pathway, and the binding of MCM protein to chromatin to exert its role. Furthermore, knockdown of HBO1 was found to reverse the effect of NCAPG2 overexpression on cell proliferation, migration, invasion, and cell cycle. In addition, knockdown of NCAPG2 attenuated glioblastoma tumorigenesis in vivo. Taken together, the findings demonstrated that NCAPG2 facilitates the malignancy of glioblastoma cells and xenograft tumor growth via HBO1 activation by phosphorylation. These results improve our understanding of the mechanism underlying glioblastoma progression and may contribute to the identification of novel biomarkers and therapeutic targets for glioblastoma.
机译：NCAPG2（non-SMC condensin II complex subunit G2）作为细胞有丝分裂的重要因子，一直是各种癌症研究的热点。然而，NCAPG2在胶质母细胞瘤细胞恶性肿瘤中的作用尚不清楚。本研究的结果表明，NCAPG2在人类胶质母细胞瘤组织中显著增加，并与不良临床结果相关。此外，NCAPG2可以促进胶质母细胞瘤细胞的增殖、迁移和侵袭，并调节细胞周期。分子机制研究表明，NCAPG2调节HBO1磷酸化和H4组蛋白乙酰化酶的激活，调节Wnt/β连环蛋白途径的激活，以及MCM蛋白与染色质的结合以发挥其作用。此外，发现敲除HBO1可逆转NCAPG2过度表达对细胞增殖、迁移、侵袭和细胞周期的影响。此外，敲除NCAPG2可减弱体内胶质母细胞瘤的肿瘤发生。总之，研究结果表明NCAPG2通过磷酸化激活HBO1促进胶质母细胞瘤细胞恶性化和异种移植瘤生长。这些结果提高了我们对胶质母细胞瘤进展机制的理解，并可能有助于识别胶质母细胞瘤的新生物标志物和治疗靶点。

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  • 来源
    《Cell and Tissue Research》 |2021年第2期|共14页
  • 作者

    Wu Jianheng; Li Linfan; Jiang Guangyuan; Zhan Hui; Zhu Xiumei; Yang Wujun;

  • 作者单位

    Peoples Hosp GaoZhou Dept Neurosurg Maoming 525200 Guangdong Peoples R China;

    Peoples Hosp GaoZhou Dept Neurosurg Maoming 525200 Guangdong Peoples R China;

    Nanxishan Hosp Dept Neurosurg Guilin 541000 Guangxi Zhuang Peoples R China;

    Peoples Hosp GaoZhou Dept Neurosurg Maoming 525200 Guangdong Peoples R China;

    Peoples Hosp GaoZhou Dept Pathol Maoming 525200 Guangdong Peoples R China;

    Wuhan Univ Enshi Clin Coll Cent Hosp Enshi Tujia &

    Miao Autonomous Prefectur Dept Neurosurg;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    NCAPG2; HBO1; Phosphorylation; Glioblastoma; Tumor growth;

    机译：NCAPG2;HBO1;磷酸化;胶质母细胞瘤;肿瘤生长;

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