Lung remodeling associated with recovery from acute lung injury

Gill Sean E.; Yamashita Cory M.; Veldhuizen Ruud A. W.

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Lung remodeling associated with recovery from acute lung injury

机译：肺重塑与急性肺损伤恢复相关

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Acute respiratory distress syndrome (ARDS) is a disease with a variety of causes and is defined by severe hypoxemia. Whereas ARDS carries a mortality of approximately 30 %, patients that survive may ultimately regain near normal pulmonary physiology. The critical pathophysiological processes in ARDS are alveolar barrier dysfunction and overwhelming inflammation. This encompasses damage to the epithelial and endothelial layers, thickening of the interstitial matrix, edema with inactivation of pulmonary surfactant at the alveolar surface and marked inflammation mediated by infiltrating neutrophils and pro-inflammatory macrophages. For patients that survive the disease, these are the critical processes that require repair and remodeling to allow for the recovery of ARDS. As such, the current review focuses on the experimental studies that have begun to elucidate the mechanisms involved in restoring the alveolar barrier following injury.

机译：急性呼吸窘迫综合征（ARDS）是一种病因多样的疾病，其定义为严重低氧血症。虽然ARDS的死亡率约为30%，但存活下来的患者最终可能恢复接近正常的肺生理。ARDS的关键病理生理过程是肺泡屏障功能障碍和严重炎症。这包括上皮和内皮层损伤、间质基质增厚、肺泡表面肺表面活性物质失活引起的水肿，以及浸润性中性粒细胞和促炎巨噬细胞介导的显著炎症。对于在疾病中存活下来的患者来说，这些都是需要修复和重塑以恢复ARDS的关键过程。因此，目前的综述侧重于已经开始阐明损伤后肺泡屏障恢复机制的实验研究。

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《Cell and Tissue Research》 |2017年第3期|共15页
作者
Gill Sean E.; Yamashita Cory M.; Veldhuizen Ruud A. W.;
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作者单位

Lawson Hlth Res Inst Ctr Crit Illness Res London ON Canada;

Lawson Hlth Res Inst Ctr Crit Illness Res London ON Canada;

Lawson Hlth Res Inst Ctr Crit Illness Res London ON Canada;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Lung repair; Acute lung Injury; Acute respiratory distress syndrome;

机译：肺修复;急性肺损伤;急性呼吸窘迫综合征;

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5. Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model [J] . Lilian Steffen, Clemens Ruppert, Heinz-Gerd Hoymann, American Journal of Physiology . 2017,第2Pta1期

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6. Indexing extravascular lung water to predicted body weight increases the correlation with lung injury score in patients with acute lung injury/acute respiratory distress syndrome: a prospective, multicenter study conducted in a Japanese population [J] . H Fukushima, T Seki, Y Urizono, Critical care : . 2011,第Suppla1期

机译：在急性肺损伤/急性呼吸窘迫综合征患者中，将血管外肺水索引为预期体重可增加与肺损伤评分的相关性：一项在日本人群中进行的前瞻性，多中心研究
7. Indexing extravascular lung water to predicted body weight increases the correlation with lung injury score in patients with acute lung injury/acute respiratory distress syndrome: a prospective, multicenter study conducted in a Japanese population [J] . H Fukushima, T Seki, Y Urizono, Critical care : . 2011,第Suppla1期

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8. Monitoring of cardiac output and lung ventilation by electrical impedance tomography in a porcine model of acute lung injury [C] . Nadine Hochhausen, Henriette Dohmeier, Rolf Rossaint, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2017

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9. Thermodynamically-Constrained Computational Modeling of Lung Tissue Bioenergetics and the Effect of Hyperoxia-Induced Acute Lung Injury [D] . Zhang, Xiao. 2019

机译：热力学约束的肺组织生物能学计算模型及高氧血症引起的急性肺损伤的作用
10. Indexing extravascular lung water to predicted body weight increases the correlation with lung injury score in patients with acute lung injury/acute respiratory distress syndrome: a prospective multicenter study conducted in a Japanese population [O] . H Fukushima, T Seki, Y Urizono, 2011

机译：在急性肺损伤/急性呼吸窘迫综合征患者中对血管外肺水进行索引以预测体重会增加与肺损伤评分的相关性：一项在日本人群中进行的前瞻性多中心研究
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机译：脓毒症致急性肺损伤组织重塑机制的研究

Lung remodeling associated with recovery from acute lung injury

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