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首页> 外文期刊>Cell and Tissue Research >Advances and clinical challenges for translating nerve conduit technology from bench to bed side for peripheral nerve repair
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Advances and clinical challenges for translating nerve conduit technology from bench to bed side for peripheral nerve repair

机译：将神经管道技术从长凳转化为外周神经修复的进展和临床挑战

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摘要

Injuries to the peripheral nervous system remain a large-scale clinical problem. These injuries often lead to loss of motor and/or sensory function that significantly affects patients' quality of life. The current neurosurgical approach for peripheral nerve repair involves autologous nerve transplantation, which often leads to clinical complications. The most pressing need is to increase the regenerative capacity of existing tubular constructs in the repair of large nerve gaps through development of tissue-engineered approaches that can surpass the performance of autografts. To fully realize the clinical potential of nerve conduit technology, there is a need to reconsider design strategies, biomaterial selection, fabrication techniques and the various potential modifications to optimize a conduit microenvironment that can best mimic the natural process of regeneration. In recent years, a significant progress has been made in the designing and functionality of bioengineered nerve conduits to bridge long peripheral nerve gaps in various animal models. However, translation of this work from lab to commercial scale has not been achieve. The current review summarizes recent advances in the development of tissue engineered nerve guidance conduits (NGCs) with regard to choice of material, novel fabrication methods, surface modifications and regenerative cues such as stem cells and growth factors to improve regeneration performance. Also, the current clinical potential and future perspectives to achieve therapeutic benefits of NGCs will be discussed in context of peripheral nerve regeneration.
机译：周围神经系统的损伤仍然是一个大规模的临床问题。这些损伤通常会导致运动和/或感觉功能丧失，严重影响患者的生活质量。目前用于周围神经修复的神经外科方法涉及自体神经移植，这通常会导致临床并发症。最迫切的需要是通过开发组织工程方法来提高现有管状结构的再生能力，以修复大的神经间隙，这种方法可以超过自体移植的性能。为了充分发挥神经导管技术的临床潜力，有必要重新考虑设计策略、生物材料选择、制造技术和各种可能的修改，以优化导管微环境，从而最好地模拟自然再生过程。近年来，在各种动物模型中，生物工程神经导管的设计和功能方面取得了重大进展，以桥接长的周围神经间隙。然而，这项工作还没有实现从实验室到商业规模的转化。本文综述了组织工程神经引导导管（NGCs）在材料选择、新型制造方法、表面修饰和再生线索（如干细胞和生长因子）方面的最新进展，以提高再生性能。此外，目前的临床潜力和未来的前景，以实现治疗效益的神经干细胞将讨论的背景下周围神经再生。

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