Improving therapeutic potential of GDNF family ligands

Runeberg-Roos Pia; Penn Richard D.

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Improving therapeutic potential of GDNF family ligands

机译：改善GDNF家族配体的治疗潜力

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摘要

The last decade has been a frustrating time for investigators who had envisioned major advances in the treatment of Parkinson's disease using neurotrophic factors. The first trials of glial cell line-derived neurotrophic factor for treating Parkinson's disease were very promising. Later blinded control trials were disappointing, not reaching the predetermined outcomes for improvement in motor function. Consideration of the problems in the studies as well as the biology of the neurotrophins used can potentially lead to more effective therapies. Parkinson's disease presents a multitude of opportunities for the cell biologist wanting to understand its pathology and to find possible new avenues for treatment.

机译：过去十年对那些曾设想使用神经营养因子治疗帕金森病取得重大进展的研究人员来说是一段令人沮丧的时期。胶质细胞源性神经营养因子治疗帕金森病的首次试验非常有希望。后来的盲对照试验令人失望，没有达到改善运动功能的预定结果。考虑到研究中的问题以及所用神经营养素的生物学特性，可能会产生更有效的治疗方法。帕金森病为细胞生物学家提供了许多机会，他们希望了解帕金森病的病理学，并找到可能的新治疗途径。

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来源
《Cell and Tissue Research》 |2020年第1期|共11页
作者
Runeberg-Roos Pia; Penn Richard D.;
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作者单位

Univ Helsinki Inst Biotechnol PB 56 Viikinkaari 5D FIN-00014 Helsinki Finland;

Rush Med Sch Chicago IL USA;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
GDNF family ligands; Parkinson's disease; Cell biology; NRTN;

机译：GDNF家庭配体;帕金森病;细胞生物学;NRTN;

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2. Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth [J] . Mona A Abbassy, Ippei Watari, Ahmed S Bakry, 国际口腔科学杂志（英文版） . 2016,第001期
3. BTLA, a New Inhibitory B7 Family Receptor with a TNFR Family Ligand [J] . Chun Zeng, Tinghe Wu, Yu Zhen, 中国免疫学杂志（英文版） . 2005,第006期
4. BTLA, a New Inhibitory B7 Family Receptor with a TNFR Family Ligand [J] . Chun, Zeng, Tinghe, 细胞与分子免疫学：英文版 . 2005,第006期
5. Small-Molecule Ligands as Potential GDNF Family Receptor Agonists [J] . Larisa Ivanova, Jaana Tammiku-Taul, Yulia Sidorova, ACS Omega . 2018,第1期

机译：小分子配体作为潜在的GDNF家族受体激动剂。
6. GDNF Family Ligands: A Potential Future for Parkinson's Disease Therapy [J] . Amanda L. Mickiewicz, Jeffrey H. Kordower CNS & neurological disorders drug targets . 2011,第6期

机译：GDNF家庭配体：帕金森氏病治疗的潜在未来
7. Glial cell line-derived neurotrophic factor family ligands and their therapeutic potential [J] . Sidorova Y. A., Saarma M. Molecular Biology . 2016,第4期

机译：胶质细胞源性神经营养因子家族配体及其治疗潜力
8. MULTIVALENT GLYCOCONJUGATES: GALECTIN LIGANDS WITH A THERAPEUTIC POTENTIAL [C] . Pavla Boiarova, Dominic Laaf, Marina R. Tavares International Carbohydrate Symposium . 2018

机译：多价糖缀合物：具有治疗潜力的Galectin配体
9. Purification and Ligand-Binding Mechanism of Family B G Protein-Coupled Receptors: Guiding the Rational Design of Peptide-Based Therapeutics [D] . Cai, Yingying 2017

机译：B G蛋白家族受体的纯化和配体结合机理：指导基于肽的药物的合理设计
10. Small-Molecule Ligands as Potential GDNF Family ReceptorAgonists [O] . Larisa Ivanova, Jaana Tammiku-Taul, Yulia Sidorova, 2018

机译：小分子配体作为潜在的GDNF家族受体。激动剂
11. Glial cell line-drived neurotrophic factor (GDNF) family of ligands is a mitogenic agent in human glioblastoma and confers chemoresistance in a ligand-specific fashion [O] . NG WAI HOE 2007

机译：胶质细胞系驱动的神经营养因子（GDNF）配体家族是人胶质母细胞瘤中的促有丝分裂剂，并以配体特异性方式赋予化学抗性
12. Testing Clinical Relevance and Therapeutic Potential of a Novel Secreted Ligand of TNF Family [R] . Yang, D. 2002

机译：检测新型TNF分泌配体的临床相关性和治疗潜力

Improving therapeutic potential of GDNF family ligands

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