...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell and Tissue Research >Structural aspects of the aging invertebrate brain
【24h】

Structural aspects of the aging invertebrate brain

机译：老化无脊椎动物的结构方面

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aging is characterized by a decline in neuronal function in all animal species investigated so far. Functional changes are accompanied by and may be in part caused by, structurally visible degenerative changes in neurons. In the mammalian brain, normal aging shows abnormalities in dendrites and axons, as well as ultrastructural changes in synapses, rather than global neuron loss. The analysis of the structural features of aging neurons, as well as their causal link to molecular mechanisms on the one hand, and the functional decline on the other hand is crucial in order to understand the aging process in the brain. Invertebrate model organisms like Drosophila and C. elegans offer the opportunity to apply a forward genetic approach to the analysis of aging. In the present review, we aim to summarize findings concerning abnormalities in morphology and ultrastructure in invertebrate brains during normal aging and compare them to what is known for the mammalian brain. It becomes clear that despite of their considerably shorter life span, invertebrates display several age-related changes very similar to the mammalian condition, including the retraction of dendritic and axonal branches at specific locations, changes in synaptic density and increased accumulation of presynaptic protein complexes. We anticipate that continued research efforts in invertebrate systems will significantly contribute to reveal (and possibly manipulate) the molecular/cellular pathways leading to neuronal aging in the mammalian brain.
机译：到目前为止，在所有研究的动物物种中，衰老的特点是神经元功能下降。功能性改变伴随着神经元结构上可见的退行性改变，并可能部分由其引起。在哺乳动物的大脑中，正常衰老表现为树突和轴突的异常，以及突触的超微结构变化，而不是整体神经元的丢失。为了理解大脑中的衰老过程，一方面分析衰老神经元的结构特征，以及它们与分子机制的因果关系，另一方面分析功能衰退是至关重要的。果蝇和秀丽隐杆线虫等无脊椎动物模式生物提供了将前向遗传方法应用于衰老分析的机会。在本综述中，我们旨在总结无脊椎动物大脑在正常衰老过程中形态学和超微结构异常的发现，并将其与已知的哺乳动物大脑进行比较。很明显，尽管无脊椎动物的寿命较短，但它们表现出与哺乳动物非常相似的几种与年龄有关的变化，包括树突和轴突分支在特定位置的收缩、突触密度的变化和突触前蛋白复合物的增加。我们预计，无脊椎动物系统的持续研究将有助于揭示（并可能操纵）导致哺乳动物大脑神经元老化的分子/细胞途径。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号