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首页> 外文期刊>Cell and Tissue Research >Unveiling diversity of stem cells in dental pulp and apical papilla using mouse genetic models: a literature review
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Unveiling diversity of stem cells in dental pulp and apical papilla using mouse genetic models: a literature review

机译：使用小鼠遗传模型揭示牙髓和顶端乳头的干细胞的多样性：文献综述

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摘要

The dental pulp, a non-mineralized connective tissue uniquely encased within the cavity of the tooth, provides a niche for diverse arrays of dental mesenchymal stem cells. Stem cells in the dental pulp, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDs) and stem cells from apical papilla (SCAPs), have been isolated from human tissues with an emphasis on their potential application to regenerative therapies. Recent studies utilizing mouse genetic models shed light on the identities of these mesenchymal progenitor cells derived from neural crest cells (NCCs) in their native conditions, particularly regarding how they contribute to homeostasis and repair of the dental tissue. The current concept is that at least two distinct niches for stem cells exist in the dental pulp, e.g., the perivascular niche and the perineural niche. The precise identities of these stem cells and their niches are now beginning to be unraveled thanks to sophisticated mouse genetic models, which lead to better understanding of the fundamental properties of stem cells in the dental pulp and the apical papilla in humans. The new knowledge will be highly instrumental for developing more effective stem cell-based regenerative therapies to repair teeth in the future.
机译：牙髓是一种非矿化的结缔组织，独特地包裹在牙齿的内腔中，为各种各样的牙齿间充质干细胞提供了一个生态位。牙髓中的干细胞，包括牙髓干细胞（DPSCs）、人乳牙脱落干细胞（SHED）和根尖乳头干细胞（SCAPs），已经从人体组织中分离出来，并强调其在再生治疗中的潜在应用。最近利用小鼠遗传模型的研究揭示了这些来源于神经嵴细胞（NCC）的间充质祖细胞在其自然条件下的特性，尤其是它们如何促进牙齿组织的内环境稳定和修复。目前的概念是，牙髓中至少存在两个不同的干细胞生态位，例如血管周围生态位和神经周围生态位。由于复杂的小鼠基因模型，这些干细胞及其生态位的确切身份现在开始被解开，这使得人们对人类牙髓和顶端乳头中干细胞的基本特性有了更好的理解。这一新知识将有助于开发更有效的干细胞再生疗法，以在未来修复牙齿。

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