Mash1-expressing cells may be relevant to type III cells and a subset of PLC beta 2-positive cell differentiation in adult mouse taste buds

Hsu Chia-Chien; Seta Yuji; Matsuyama Kae; Kataoka Shinji; Nakatomi Mitsushiro; Toyono Takashi; Gunjigake Kaori K.; Kuroishi Kayoko N.; Kawamoto Tatsuo

首页> 外文期刊>Cell and Tissue Research >Mash1-expressing cells may be relevant to type III cells and a subset of PLC beta 2-positive cell differentiation in adult mouse taste buds

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Mash1-expressing cells may be relevant to type III cells and a subset of PLC beta 2-positive cell differentiation in adult mouse taste buds

机译：表达MASH1表达的细胞与III型细胞和成年小鼠味蕾的PLCβ2阳性细胞分化的子集是相关的

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Mammalian taste bud cells have a limited lifespan and differentiate into type I, II, and III cells from basal cells (type IV cells) (postmitotic precursor cells). However, little is known regarding the cell lineage within taste buds. In this study, we investigated the cell fate ofMash1-positive precursor cells utilizing the Cre-loxP system to explore the differentiation of taste bud cells. We found thatMash1-expressing cells in Ascl1(CreERT2)::CAG-floxed tdTomato mice differentiated into taste bud cells that expressed aromatic(L)-amino acid decarboxylase (AADC) and carbonic anhydrase IV (CA4) (type III cell markers), but did not differentiate into most of gustducin (type II cell marker)-positive cells. Additionally, we found thatMash1-expressing cells could differentiate into phospholipase C beta 2 (PLC beta 2)-positive cells, which have a shorter lifespan compared with AADC- and CA4-positive cells. These results suggest thatMash1-positive precursor cells could differentiate into type III cells, but not into most of type II cells, in the taste buds.

机译：哺乳动物味蕾细胞的寿命有限，从基底细胞（IV型细胞）（有丝分裂后的前体细胞）分化为I型、II型和III型细胞。然而，关于味蕾内的细胞谱系知之甚少。在本研究中，我们利用Cre-loxP系统研究了MASH1阳性前体细胞的细胞命运，以探索味蕾细胞的分化。我们发现Ascl1（CreERT2）中MASH1表达细胞：CAG絮凝的tdTomato小鼠分化为味蕾细胞，表达芳香族（L）-氨基酸脱羧酶（AADC）和碳酸酐酶IV（CA4）（III型细胞标记物），但没有分化为大多数gustducin（II型细胞标记物）阳性细胞。此外，我们发现表达MASH1的细胞可以分化为磷脂酶Cβ2（PLCβ2）阳性细胞，与AADC和CA4阳性细胞相比，后者的寿命更短。这些结果表明，MASH1阳性前体细胞可以在味蕾中分化为III型细胞，但不能分化为大多数II型细胞。

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来源
《Cell and Tissue Research》 |2021年第2期|共9页
作者
Hsu Chia-Chien; Seta Yuji; Matsuyama Kae; Kataoka Shinji; Nakatomi Mitsushiro; Toyono Takashi; Gunjigake Kaori K.; Kuroishi Kayoko N.; Kawamoto Tatsuo;
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作者单位

Kyushu Dent Univ Div Orofacial Funct &

Orthodont Kokurakita Ku 2-6-1 Manazuru Kitakyushu;

Kyushu Dent Univ Dept Hlth Impmvement Div Anat Kokurakita Ku 2-6-1 Manazuru Kitakyushu;

Kyushu Dent Univ Dept Hlth Impmvement Div Anat Kokurakita Ku 2-6-1 Manazuru Kitakyushu;

Kyushu Dent Univ Dept Hlth Impmvement Div Anat Kokurakita Ku 2-6-1 Manazuru Kitakyushu;

Kyushu Dent Univ Dept Hlth Impmvement Div Anat Kokurakita Ku 2-6-1 Manazuru Kitakyushu;

Kyushu Dent Univ Dept Hlth Impmvement Div Anat Kokurakita Ku 2-6-1 Manazuru Kitakyushu;

Kyushu Dent Univ Div Orofacial Funct &

Orthodont Kokurakita Ku 2-6-1 Manazuru Kitakyushu;

Kyushu Dent Univ Div Orofacial Funct &

Orthodont Kokurakita Ku 2-6-1 Manazuru Kitakyushu;

Kyushu Dent Univ Div Orofacial Funct &

Orthodont Kokurakita Ku 2-6-1 Manazuru Kitakyushu;

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正文语种 eng
中图分类细胞生物学;
关键词
Mash1; bHLH transcription factor; Taste bud; Fate maping; Cell lineage;

机译：mash1;bhlh转录因子;味蕾;命运映射;细胞谱系;

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6. Mash1-expressing cells could differentiate to type III cells in adult mouse taste buds [J] . Hiroki Takagi, Yuji Seta, Shinji Kataoka, Anatomical science international . 2018,第4期

机译：表达MASH1的细胞可以将成年小鼠味蕾中的III型细胞分化为III型细胞
7. Mash1 is required for the differentiation of AADC-positive type III cells in mouse taste buds. [J] . Seta Y, Oda M, Kataoka S, Developmental dynamics: an official publication of the American Association of Anatomists . 2011,第4期

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Mash1-expressing cells may be relevant to type III cells and a subset of PLC beta 2-positive cell differentiation in adult mouse taste buds

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