Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways

Cao Yu; Zhang Yan; Ma Lijun; Wang Jiaxin; Guo Wenjin; Cheng Ji; Hu Guiqiu; Fu Shoupeng; Liu Juxiong

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Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways

机译：烟酸通过激活AKT / MTOR和ERK1 / 2信号传导途径刺激Pubertal小鼠的Eph4ev乳腺上皮细胞增殖和乳腺发育

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Previous studies have shown the effects of vitamins on the development of the mammary gland. However, the role of niacin in this process has not been reported. Therefore, the aim of this study is to investigate the effects of niacin on mammary gland development in pubertal mice and to use a mouse mammary epithelial cell line to study the underlying mechanism. The results showed that niacin could activate the AKT/mTOR and ERK signaling pathways and increase phosphorylation of 4EBP1 to promote the synthesis of cell proliferation markers, leading to the dissociation of the Rb-E2F1 complex in mMECs. In addition, 0.5% niacin promoted mammary duct development, increased the expression of cyclin D1/D3 and PCNA and activated Akt/mTOR and ERK1/2 in the mammary glands of pubertal mice. These results strongly suggest that niacin stimulates mammary gland development in pubertal mice through the Akt/mTOR and ERK1/2 signaling pathways.

机译：以前的研究已经表明维生素对乳腺发育的影响。然而，烟酸在这个过程中的作用还没有报道。因此，本研究的目的是研究烟酸对青春期小鼠乳腺发育的影响，并利用小鼠乳腺上皮细胞系研究其潜在机制。结果表明，烟酸能激活AKT/mTOR和ERK信号通路，增加4EBP1的磷酸化，促进细胞增殖标记物的合成，导致MMEC中Rb-E2F1复合物的解离。此外，0.5%的烟酸促进青春期小鼠乳腺导管发育，增加细胞周期蛋白D1/D3和PCNA的表达，激活Akt/mTOR和ERK1/2。这些结果强烈表明，烟酸通过Akt/mTOR和ERK1/2信号通路刺激青春期小鼠乳腺发育。

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来源
《Cell and Tissue Research》 |2021年第2期|共12页
作者
Cao Yu; Zhang Yan; Ma Lijun; Wang Jiaxin; Guo Wenjin; Cheng Ji; Hu Guiqiu; Fu Shoupeng; Liu Juxiong;
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作者单位

Jilin Univ Coll Vet Med Changchun 130062 Peoples R China;

Jilin Univ Hosp Stomatol Changchun 130021 Peoples R China;

Jilin Univ Coll Vet Med Changchun 130062 Peoples R China;

Jilin Univ Coll Vet Med Changchun 130062 Peoples R China;

Jilin Univ Coll Vet Med Changchun 130062 Peoples R China;

Jilin Univ Coll Vet Med Changchun 130062 Peoples R China;

Jilin Univ Coll Vet Med Changchun 130062 Peoples R China;

Jilin Univ Coll Vet Med Changchun 130062 Peoples R China;

Jilin Univ Coll Vet Med Changchun 130062 Peoples R China;

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正文语种 eng
中图分类细胞生物学;
关键词
Niacin; Mammary gland development; Akt; mTOR; ERK1; 2; Pubertal mice;

机译：烟酸;乳腺发育;akt;mtor;erk1;2;pubertal小鼠;

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机译：硬脂酸通过抑制pi3k / akt信号通路通过普格塔尔小鼠的GPR120抑制乳腺腺体
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机译：不饱和脂肪酸通过ERK1 / 2和Akt途径促进牛乳腺上皮细胞的增殖
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机译：PI3K / AKT / MTOR信号通路与典型TLRS / NF-Kappa B途径在乳腺上皮细胞中参与乳腺癌诱导的炎症
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Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways

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