Modulation of PD-1/PD-L1 axis in myeloid-derived suppressor cells by anti-cancer treatments

Jachetti Elena; Sangaletti Sabina; Chiodoni Claudia; Ferrara Roberto; Colombo Mario P.

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Modulation of PD-1/PD-L1 axis in myeloid-derived suppressor cells by anti-cancer treatments

机译：通过抗癌治疗调节髓样衍生抑制细胞中的PD-1 / PD-L1轴

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Immuno checkpoint blockade (ICB) targeting the PD-1/PD-L1 axis is the main breakthrough for the treatment of several cancers. Nevertheless, not all patients benefit from this treatment and clinical response not always correlates with PD-L1 expression by tumor cells. The tumor microenvironment, including myeloid derived suppressor cells (MDSCs), can influence therapeutic resistance to ICB. MDSCs also express PD-L1, which contributes to their suppressive activity. Moreover, anticancer therapies including chemotherapy, radiotherapy, hormone-and targeted-therapies can modulate MDSCs recruitment, activity and PD-L1 expression. Such effects can be induced also by innovative anticancer treatments targeting metabolism and lifestyle. The outcome on cancer progression can be either positive or negative, depending on tumor type, treatment schedule and possible combination with ICB. Further studies are needed to better understand the effects of cancer therapies on the PD1/PD-L1 axis, to identify patients that could benefit from combinatorial regimens including ICB or that rather should avoid it.

机译：针对PD-1/PD-L1轴的免疫检查点阻断（ICB）是几种癌症治疗的主要突破。然而，并不是所有患者都能从这种治疗中获益，临床反应并不总是与肿瘤细胞的PD-L1表达相关。肿瘤微环境，包括骨髓源性抑制细胞（MDSCs），可以影响对ICB的治疗耐药性。骨髓间充质干细胞也表达PD-L1，这有助于它们的抑制活性。此外，包括化疗、放疗、激素和靶向治疗在内的抗癌治疗可以调节MDSCs的募集、活性和PD-L1表达。这种效应也可以通过针对新陈代谢和生活方式的创新抗癌治疗来诱导。癌症进展的结果可能是积极的，也可能是消极的，这取决于肿瘤类型、治疗计划以及可能与ICB的结合。需要进一步的研究来更好地了解癌症治疗对PD1/PD-L1轴的影响，以确定哪些患者可以从包括ICB在内的组合疗法中获益，或者应该避免。

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来源
《Cellular immunology》 |2021年第1期|共10页
作者
Jachetti Elena; Sangaletti Sabina; Chiodoni Claudia; Ferrara Roberto; Colombo Mario P.;
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作者单位

Fdn IRCCS Ist Nazl Tumori Dept Res Mol Immunol Unit Via Amadeo 42 I-20133 Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Res Mol Immunol Unit Via Amadeo 42 I-20133 Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Res Mol Immunol Unit Via Amadeo 42 I-20133 Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Res Mol Immunol Unit Via Amadeo 42 I-20133 Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Res Mol Immunol Unit Via Amadeo 42 I-20133 Milan Italy;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
MDSC; PD-1; PD-L1; Cancer; Immunotherapy;

机译：MDSC;PD-1;PD-L1;癌症;免疫疗法;

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12. Myeloid-Derived Suppressor Cells in Checkpoint Protein Inhibition for Melanoma. [R] . Weber, J. 2017

机译：骨髓来源的抑制细胞检测点蛋白抑制黑色素瘤。

Modulation of PD-1/PD-L1 axis in myeloid-derived suppressor cells by anti-cancer treatments

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