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首页> 外文期刊>Cellular immunology >A novel mimovirus encoding ChgA 10–19 peptide with PD-L1 induces T cell tolerance and ameliorates the severity of diabetes
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A novel mimovirus encoding ChgA 10–19 peptide with PD-L1 induces T cell tolerance and ameliorates the severity of diabetes

机译：编码CHGA 10-19肽的新型MIMoVirus，具有PD-L1诱导T细胞耐受性并改善糖尿病的严重程度

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摘要

Highlights ? Transduced DCs attenuated CD8+ T cell activation and proliferation. ? Transduced DCs inhibited CD8+ T response to ChgA stimulation, and ameliorated the severity of diabetes. ? Mimovirus transduced DCs might provide novel clues for T1D therapy. Abstract Related studies demonstrate that type 1 diabetes (T1D) is caused by β-cell antigen specific autoreactive CD8+ T cells. ChgA has recently been identified as the autoantigen in NOD mice and T1D patients. Therefore, attenuating the activation of ChgA specific CD8+ T cells might be a promising target for T1D therapy. The negative co-stimulatory PD-L1 inhibits T cell mediated alloimmunity and induces tolerance. In this experiment, a novel mimovirus encoding ChgA 10–19 peptide with PD-L1 was constructed. The NOD.β2m null HHD mice were administrated with mimovirus transduced DCs. After immunization, the activation and proliferation of CD8+ T cells were detected, diabetes incidence and pancreatic tissue destruction were also analyzed. The results demonstrated that transduced DCs attenuated CD8+ T cell activation and proliferation. In addition, transduced DCs inhibited CD8+ T response to ChgA stimulation, and ameliorated the severity of diabetes. These data suggested that mimovirus transduced DCs might provide novel clues for T1D therapy.
机译：亮点？转导的树突状细胞减弱CD8+T细胞的活化和增殖？转导的DC抑制CD8+T对ChgA刺激的反应，并改善糖尿病的严重程度？微小病毒转导的DC可能为T1D治疗提供新线索。摘要相关研究表明，1型糖尿病（T1D）是由β细胞抗原特异性自身反应性CD8+T细胞引起的。ChgA最近被确认为NOD小鼠和T1D患者的自身抗原。因此，减弱ChgA特异性CD8+T细胞的激活可能是T1D治疗的一个有希望的靶点。负性共刺激PD-L1抑制T细胞介导的同种异体免疫并诱导耐受。在本实验中，构建了编码ChgA 10–19肽和PD-L1的新型微小病毒。点头。 免疫后检测CD8+T细胞的活化和增殖，分析糖尿病发病率和胰腺组织破坏情况。结果表明，转导的DC减弱了CD8+T细胞的活化和增殖。此外，转导的DC抑制了CD8+T对ChgA刺激的反应，并改善了糖尿病的严重程度。这些数据表明，微小病毒转导的DC可能为T1D治疗提供新的线索。

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  • 来源
    《Cellular immunology》 |2017年第2017期|共6页
  • 作者

    Hong Sun; Xiaoguang Han; Xiuhui Yan; Jingli Xu; Qiujing Huang; Fanqing Meng; Hongjin Zhang; Shufa Li;

  • 作者单位

    Department of Outpatient The Third People’s Hospital of Linyi;

    Department of Endocrinology and Metabolism The Third People’s Hospital of Linyi;

    Department of Obstetrics and Gynecology The Third People’s Hospital of Linyi;

    Department of Endocrinology and Metabolism The Third People’s Hospital of Linyi;

    Department of Endocrinology and Metabolism The Third People’s Hospital of Linyi;

    Department of Endocrinology and Metabolism The Third People’s Hospital of Linyi;

    Department of Endocrinology and Metabolism The Third People’s Hospital of Linyi;

    Department of Endocrinology and Metabolism The Third People’s Hospital of Linyi;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Mimovirus; ChgA10–19; PD-L1; T cell tolerance; Diabetes;

    机译：Mimovirus;CHGA10-19;PD-L1;T细胞耐受性;糖尿病;

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