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Resveratrol inhibits lung cancer growth by suppressing M2-like polarization of tumor associated macrophages

机译：白藜芦醇通过抑制肿瘤相关巨噬细胞的M2样极化来抑制肺癌生长

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摘要

In cancer, tumor associated macrophages (TAMs) play an important role in the cancer progression, evasion of immunity and dissemination of cancer cells. Inhibition of the activation or the M2 polarization of TAMs is an effective therapy for cancer. In the present study, we investigated the ability of resveratrol (RES) to inhibit lung cancer growth using in vitro and in vivo studies, and examined the underlying mechanisms. We demonstrated that M2 polarization of human monocyte derived macrophage (HMDMs) induced by the lung cancer cells conditioned medium was inhibited by RES. Additionally, RES exhibited inhibitory function in lung cancer cells co-cultured with human macrophages. The activity of signal transducer and activator of transcription 3 (STAT3) was significantly decreased by RES. Moreover, in a mouse lung cancer xenograft model, RES significantly inhibited the tumor growth, which was associated with inhibition of cell proliferation and decreased expression of p-STAT3 in tumor tissues. Further, RES inhibits F4/80 positive expressing cells and M2 polarization in the tumors. These results suggest that RES can effectively inhibit lung cancer progression by suppressing the protumor activation of TAMs. (C) 2016 Elsevier Inc. All rights reserved.
机译：在癌症中，肿瘤相关巨噬细胞（TAM）在癌症进展、免疫逃避和癌细胞扩散中起着重要作用。抑制TAMs的激活或M2极化是治疗癌症的有效方法。在本研究中，我们通过体外和体内研究，研究了白藜芦醇（RES）抑制肺癌生长的能力，并探讨了其潜在机制。我们证明，RES抑制了肺癌细胞条件培养液诱导的人单核细胞源性巨噬细胞（HMDMs）的M2极化。此外，RES在与人巨噬细胞共培养的肺癌细胞中表现出抑制功能。RES显著降低信号转导子和转录激活子3（STAT3）的活性。此外，在小鼠肺癌异种移植模型中，RES显著抑制肿瘤生长，这与抑制细胞增殖和降低肿瘤组织中p-STAT3的表达有关。此外，RES抑制肿瘤中F4/80阳性表达细胞和M2极化。这些结果表明，RES可以通过抑制肿瘤前体TAMs的激活有效地抑制肺癌的进展。（C） 2016爱思唯尔公司版权所有。

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  • 来源
    《Cellular immunology》 |2017年第2017期|共8页
  • 作者

    Sun Liwei; Chen Bonian; Jiang Rong; Li Jinduo; Wang Bin;

  • 作者单位

    Tianjin Huanhu Hosp Dept Intervent Tianjin Key Lab Cerebral Vasc &

    Neurodegenerat Di Tianjin;

    Tianjin Huanhu Hosp Dept Intervent Tianjin Key Lab Cerebral Vasc &

    Neurodegenerat Di Tianjin;

    Tianjin Huanhu Hosp Dept Intervent Tianjin Key Lab Cerebral Vasc &

    Neurodegenerat Di Tianjin;

    Tianjin Huanhu Hosp Dept Intervent Tianjin Key Lab Cerebral Vasc &

    Neurodegenerat Di Tianjin;

    Tianjin Huanhu Hosp Dept Intervent Tianjin Key Lab Cerebral Vasc &

    Neurodegenerat Di Tianjin;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Resveratrol; Lung cancer; STAT3; Macrophages;

    机译：白藜芦醇;肺癌;stat3;巨噬细胞;

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