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首页> 外文期刊>Cellular immunology >Myeloperoxidase: A new player in autoimmunity
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Myeloperoxidase: A new player in autoimmunity

机译：myeloperoxidase：自身免疫的新球员

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摘要

Myeloperoxidase (MPO) is the most toxic enzyme found in the azurophilic granules of neutrophils. MPO utilizes H2O2 to generate hypochlorous acid (HC10) and other reactive moieties, which kill pathogens during infections. In contrast, in the setting of sterile inflammation, MPO and MPO-derived oxidants are thought to be pathogenic, promoting inflammation and causing tissue damage. In contrast, evidence also exists that MPO can limit the extent of immune responses. Elevated MPO levels and activity are observed in a number of autoimmune diseases including in the central nervous system (CNS) of multiple sclerosis (MS) and the joints of rheumatoid arthritis (RA) patients. A pathogenic role for MPO in driving autoimmune inflammation was demonstrated using mouse models. Mechanisms whereby MPO is thought to contribute to disease pathogenesis include tuning of adaptive immune responses and/or the induction of vascular permeability.
机译：髓过氧化物酶（MPO）是中性粒细胞嗜蓝颗粒中毒性最强的酶。MPO利用H2O2生成次氯酸（HC10）和其他活性部分，在感染期间杀死病原体。相比之下，在无菌炎症环境中，MPO和MPO衍生的氧化剂被认为是致病性的，促进炎症并导致组织损伤。相比之下，还有证据表明MPO可以限制免疫反应的程度。在许多自身免疫性疾病中观察到MPO水平和活性升高，包括多发性硬化症（MS）的中枢神经系统（CNS）和类风湿性关节炎（RA）患者的关节。用小鼠模型证实了MPO在驱动自身免疫炎症中的致病作用。MPO被认为有助于疾病发病机制的机制包括调节适应性免疫反应和/或诱导血管通透性。

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