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首页> 外文期刊>Cellular immunology >Monocytic myeloid-derived suppressor cells home to tumor-draining lymph nodes via CCR2 and locally modulate the immune response
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Monocytic myeloid-derived suppressor cells home to tumor-draining lymph nodes via CCR2 and locally modulate the immune response

机译：单核细胞霉菌衍生的抑制细胞通过CCR2和局部调节免疫应答的肿瘤排出淋巴结的所在地

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Efficient priming of anti-tumor T cells requires the uptake and presentation of tumor antigens by immunogenic dendritic cells (DCs) and occurs mainly in lymph nodes draining the tumor (tdLNs). However, tumors expand and activate myeloid-derived suppressor cells (MDSCs) that inhibit CTL functions by several mechanisms. While the immune-suppressive nature of the tumor microenvironment is largely documented, it is not known whether similar immune-suppressive mechanisms operate in the tdLNs. In this study, we analyzed MDSC characteristics within tdLNs. We show that, in a metastasis-free context, MO-MDSCs are the dominant MDSC population within tdLNs, that they are highly suppressive and that tumor proximity enhances their recruitment to tdLN via a CCR2/ CCL2-dependent pathway. Altogether our results uncover a mechanism by which tumors evade the immune system that involves MDSC-mediated recruitment to the tdLN and the inhibition of T-cell activation even before reaching the highly immunosuppressive tumor microenvironment.
机译：有效启动抗肿瘤T细胞需要免疫原性树突状细胞（DC）摄取和呈现肿瘤抗原，主要发生在引流肿瘤的淋巴结（TDLN）中。然而，肿瘤通过多种机制扩展和激活骨髓源性抑制细胞（MDSCs），抑制CTL功能。虽然肿瘤微环境的免疫抑制性质在很大程度上已被记录，但尚不清楚类似的免疫抑制机制是否在TDLN中起作用。在本研究中，我们分析了TDLN中的MDSC特性。我们发现，在无转移的情况下，MO-MDSC是tdLN中占主导地位的MDSC群体，它们具有高度抑制性，并且肿瘤邻近性通过CCR2/CCL2依赖性途径增强了它们向tdLN的募集。总之，我们的研究结果揭示了一种肿瘤逃避免疫系统的机制，这种机制涉及MDSC介导的tdLN招募和T细胞激活抑制，甚至在到达高度免疫抑制的肿瘤微环境之前。

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