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CD8+T cells: The past and future of immune regulation

机译:CD8 + T细胞:免疫调节的过去和未来

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摘要

Regulation of the adaptive immune response is critical for health. Regulatory activity can be found in multiple components of the immune system, however, the focus on particular components of the immune regulatory network has left many aspects of this critical immune component understudied. Here we review the evidence for activities of CD8 + T cells in immune homeostasis and regulation of autoimmune reactivity. The heterogeneous nature of identified CD8 + cell types are examined, and common phenotypes associated with functional activities are defined. The varying types of antigen signal crucial for CD8 + T cell regulatory activity are identified and the implications of these activation pathways for control of adaptive responses is considered. Finally, the promising capacity for transgenic antigen receptor directed cytotoxicity as a mechanism for modulation of autoimmunity is detailed.
机译:调节适应性免疫反应对健康至关重要。调节活性存在于免疫系统的多个组成部分中,然而,由于对免疫调节网络的特定组成部分的关注,这一关键免疫组成部分的许多方面尚未得到研究。在这里,我们回顾了CD8+T细胞在免疫稳态和自身免疫反应调节中的活动证据。研究了已鉴定的CD8+细胞类型的异质性,并定义了与功能活动相关的常见表型。确定了对CD8+T细胞调节活性至关重要的不同类型的抗原信号,并考虑了这些激活途径对控制适应性反应的影响。最后,详细介绍了转基因抗原受体导向的细胞毒性作为自身免疫调节机制的前景。

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