Radiotherapy and cGAS/STING signaling: Impact on MDSCs in the tumor microenvironment

Kho Vera M.; Mekers Vera E.; Span Paul N.; Bussink Johan; Adema Gosse J.

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Radiotherapy and cGAS/STING signaling: Impact on MDSCs in the tumor microenvironment

机译：放射疗法和CGAS / Sting Signaling：对肿瘤微环境的影响对MDSCS

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Myeloid derived suppressor cells (MDSCs) are a highly heterogeneous population of immature immune cells with immunosuppressive functions that are recruited to the tumor microenvironment (TME). MDSCs promote tumor growth and progression by inhibiting immune effector cell proliferation and function. MDSCs are affected by both novel anti-cancer therapies targeting the immune system to promote anti-tumor immunity, as well as by conventional treatments such as radiotherapy. Following radiotherapy, cytoplasmic double stranded DNA stimulates the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway, resulting in type I interferon production. Effectiveness of radiotherapy and cGAS/STING signaling are closely intertwined: activation of cGAS and STING is key to generate systemic anti-tumor immunity after irradiation. This review focuses on how radiotherapy and cGAS/STING signaling in MDSCs and/or tumor cells impact MDSC recruitment, expansion and function. The influence of conventional and ablative radiotherapy treatment schedules, inflam-matory response following radiotherapy, and hypoxia are discussed as MDSC modulators.

机译：髓源性抑制细胞（MDSCs）是一种高度异质性的未成熟免疫细胞群，具有免疫抑制功能，被招募到肿瘤微环境（TME）中。骨髓间充质干细胞通过抑制免疫效应细胞增殖和功能促进肿瘤生长和进展。骨髓间充质干细胞既受到以免疫系统为靶点的新型抗癌疗法的影响，以促进抗肿瘤免疫，也受到放疗等常规疗法的影响。放疗后，细胞质双链DNA刺激环GMP-AMP合酶（cGAS）/干扰素基因刺激因子（STING）通路，导致I型干扰素的产生。放疗的有效性和cGAS/STING信号密切相关：cGAS和STING的激活是放疗后产生全身抗肿瘤免疫的关键。本文综述了放射治疗和骨髓间充质干细胞和/或肿瘤细胞中的cGAS/STING信号如何影响骨髓间充质干细胞的募集、扩增和功能。作为MDSC调节剂，讨论了常规和消融放疗治疗方案、放疗后炎症反应和缺氧的影响。

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来源
《Cellular immunology》 |2021年第1期|共9页
作者
Kho Vera M.; Mekers Vera E.; Span Paul N.; Bussink Johan; Adema Gosse J.;
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作者单位

Radboud Univ Nijmegen Med Ctr Dept Radiat Oncol Radiotherapy &

OncoImmunol Lab Geert Grootepl;

Radboud Univ Nijmegen Med Ctr Dept Radiat Oncol Radiotherapy &

OncoImmunol Lab Geert Grootepl;

Radboud Univ Nijmegen Med Ctr Dept Radiat Oncol Radiotherapy &

OncoImmunol Lab Geert Grootepl;

Radboud Univ Nijmegen Med Ctr Dept Radiat Oncol Radiotherapy &

OncoImmunol Lab Geert Grootepl;

Radboud Univ Nijmegen Med Ctr Dept Radiat Oncol Radiotherapy &

OncoImmunol Lab Geert Grootepl;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
MDSC; Radiotherapy; Tumor microenvironment; cGAS; STING; Immune system; Cancer; Immunotherapy;

机译：MDSC;放疗;肿瘤微环境;CGA;刺痛;免疫系统;癌症;免疫疗法;

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2. Activated cytotoxic lymphocytes promote tumor progression by increasing the ability of 3LL tumor cells to mediate MDSC chemoattraction via Fas signaling [J] . Fei Yang, Yinxiang Wei, Zhijian Cai, 细胞与分子免疫学：英文版 . 2015,第001期
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机译：CGAS-STING肿瘤微环境中的活化及其在癌症免疫中的作用
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机译：CGAS-Sting在肿瘤微环境中的激活及其在癌症免疫中的作用（Vol 1024，PG 175,2017）
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机译：无细胞肿瘤微粒疫苗通过cGAS / STING信号刺激树突状细胞
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机译：P2.04-23肿瘤 - 基质相互作用促进肺肿瘤微环境中CGAS-Sting驱动的炎症
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机译：肿瘤微环境和FGF信号轴对前列腺癌神经内分泌表型分化和出现的作用

Radiotherapy and cGAS/STING signaling: Impact on MDSCs in the tumor microenvironment

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