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首页> 外文期刊>Cellular immunology >Trauma-induced vestibular dysfunction: Possible functional repair under alpha 1-antitrypsin-rich conditions
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Trauma-induced vestibular dysfunction: Possible functional repair under alpha 1-antitrypsin-rich conditions

机译：创伤诱导的前庭功能障碍：在富含α-抗抗糖蛋白的条件下可能的功能性修复

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摘要

Transient vestibular organ deafferentation, such that is caused by traumatic tissue injury, is presently addressed by corticosteroid therapy. However, restoration of neurophysiological properties is rarely achieved. Here, it was hypothesized that the tissue-protective attributes of alpha 1-antityrpsin (AAT) may promote restoration of neuronal function. Inner ear injury was inflicted by unilateral labyrinthotomy in wild-type mice and in mice over-expressing human AAT. A 2-week-long assessment of vestibular signs followed. All animals responded with peak vestibular dysfunction scores within 4 h after local trauma. While wild-type animals displayed partial or no recovery across 7 days post-injury, AAT-rich group exhibited early recovery: from behavioral score 9-out-of-9 at peak to 4.8 +/- 0.44 (mean +/- SD) within 8 h from injury, a time when wild-type mice scored 8.6 +/- 0.54 (p < 0.0001), and from vestibular score 15-out-of-15 to 7.8 +/- 2.2 within 24 h, when wild-type mice scored 13.0 +/- 2.0 (p < 0.01). Thus, recovery and functional normalisation of an injured vestibular compartment is achievable without corticosteroid therapy; expedited tissue repair processes appear to result from elevated circulating AAT levels. This study lays the foundation for exploring the molecular and cellular mediators of AAT within the repair processes of the delicate microscopic structures of the vestibular end organ.
机译：暂时性前庭器官去传入是由创伤性组织损伤引起的，目前皮质类固醇治疗可以解决这一问题。然而，神经生理特性的恢复很少实现。在这里，我们假设α1-抗胰蛋白酶（AAT）的组织保护属性可能促进神经元功能的恢复。在野生型小鼠和过度表达人类AAT的小鼠中，通过单侧迷路切开造成内耳损伤。随后进行为期两周的前庭体征评估。所有动物在局部创伤后4小时内前庭功能障碍评分均达到峰值。虽然野生型动物在受伤后7天内表现出部分恢复或没有恢复，但富含AAT的组表现出早期恢复：在受伤后8小时内，从9分中的9分行为评分到4.8+/-0.44（平均+/-SD），野生型小鼠评分为8.6+/-0.54（p<0.0001），在24小时内，前庭评分从15分中的15分到7.8+/-2.2，野生型小鼠得分为13.0+/-2.0（p<0.01）。因此，受伤前庭室的恢复和功能正常化无需皮质类固醇治疗即可实现；加速组织修复过程似乎是循环AAT水平升高的结果。本研究为探索AAT在前庭末梢器官精细结构修复过程中的分子和细胞介质奠定了基础。

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