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首页> 外文期刊>Cellular immunology >Signal Inhibitory Receptor on Leukocytes-1 is highly expressed on lung monocytes, but absent on mononuclear phagocytes in skin and colon
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Signal Inhibitory Receptor on Leukocytes-1 is highly expressed on lung monocytes, but absent on mononuclear phagocytes in skin and colon

机译：白细胞-1上的信号抑制受体在肺单核细胞上高度表达，但在皮肤和结肠中的单核吞噬细胞中缺乏

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Signal Inhibitory Receptor on Leukocytes-1 (SIRL-1) is expressed on human blood monocytes and granulocytes and inhibits myeloid effector functions. On monocytes, but not granulocytes, SIRL-1 expression is low or absent in individuals with the single nucleotide polymorphism (SNP) rs612529C. The expression of SIRL-1 in tissue and the influence of rs612529 hereon is currently unknown. Here, we used flow cytometry to determine SIRL-1 expression on immune cells in human blood and three barrier tissues; skin, colon and lung. SIRL-1 was expressed by virtually all neutrophils and eosinophils in these tissues. In contrast, SIRL-1 was not expressed by monocyte-derived cells in skin and colon, whereas it was highly expressed by lung classical monocytes. Lung monocytes from individuals with a rs612529C allele had decreased SIRL-1 expression, consistent with the genotype association in blood. Within the different monocyte subsets in blood and lung, SIRL-1 expression was highest in classical monocytes and lowest in nonclassical monocytes. SIRL-1 was not expressed by dendritic cells in blood and barrier tissues. Together, these results indicate that SIRL-1 is differentially expressed on phagocyte subsets in blood and barrier tissues, and that its expression on monocytes is genotype- and tissue-specific. Immune regulation of monocytes by SIRL-1 may be of particular importance in the lung.
机译：白细胞信号抑制受体-1（SIRL-1）在人血单核细胞和粒细胞上表达，并抑制髓系效应器功能。在单核细胞（而非粒细胞）上，单核苷酸多态性（SNP）rs612529C个体的SIRL-1表达较低或缺失。目前尚不清楚SIRL-1在组织中的表达以及rs612529的影响。在这里，我们使用流式细胞术来测定人类血液和三种屏障组织中免疫细胞上SIRL-1的表达；皮肤、结肠和肺。在这些组织中，几乎所有的中性粒细胞和嗜酸性粒细胞都表达SIRL-1。相比之下，SIRL-1在皮肤和结肠的单核细胞源性细胞中不表达，而在肺的单核细胞中高表达。来自rs612529C等位基因个体的肺单核细胞的SIRL-1表达降低，这与血液中的基因型关联一致。在血液和肺的不同单核细胞亚群中，SIRL-1在经典单核细胞中表达最高，在非经典单核细胞中表达最低。在血液和屏障组织中，树突状细胞不表达SIRL-1。总之，这些结果表明，SIRL-1在血液和屏障组织的吞噬细胞亚群上有差异表达，在单核细胞上的表达具有基因型和组织特异性。SIRL-1对单核细胞的免疫调节在肺中可能特别重要。

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