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Engagement of lymphoma T cell receptors causes accelerated growth and the secretion of an NK cell-inhibitory factor

机译：淋巴瘤T细胞受体的参与会导致加速生长和NK细胞抑制因子的分泌

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摘要

The development of T cell lymphomas in mice that constitutively express a single T cell receptor is surveilled by the action of NK cells. We investigated the effects of engaging the lymphoma TCR in this mouse model. We stimulated lymphoma cells expressing an ovalbumin-specific TCR in vivo using listeria monocytogenes as a vehicle. Infections with listeria expressing ovalbumin but not with control bacteria caused a stable change in lymphoma cells that allowed its growth in mice with normal NK cells. TCR engagement furthermore enhanced lymphoma growth in NK-cell-depleted mice suggesting a lymphoma-intrinsic change that lead to accelerated growth. The ability to grow in mice without prior NK cell depletion did not appear to be accompanied by changes in the recognition of lymphoma by NK cells. Rather, lymphoma immunization was associated with a decrease in NK cell numbers: Leukemic phases were observed for all mice starting three to eight weeks after immunizations, and leukemias were succeeded by the disappearance of NK cells from blood. We also observed strong decreases of NK cell numbers in spleens at the time of death. Co-culture experiments showed decreases in the ability of NK cells to proliferate in response to IL-15 when post-immunization lymphoma cells were present in a mechanism that did not require direct cell contact. Together these data suggest that TCR engagement caused intrinsic changes in T cell lymphoma cells resulting in both accelerated in vivo growth and in the secretion of a factor that caused NK cell disappearance.
机译：在组成性表达单个T细胞受体的小鼠中，T细胞淋巴瘤的发生是通过NK细胞的作用来监测的。我们在这个小鼠模型中研究了淋巴瘤TCR的作用。我们以单核细胞增生李斯特菌为载体，在体内刺激表达卵清蛋白特异性TCR的淋巴瘤细胞。感染表达卵清蛋白的李斯特菌，但不感染对照细菌，导致淋巴瘤细胞发生稳定变化，使其在正常NK细胞的小鼠中生长。TCR参与进一步增强了NK细胞缺失小鼠的淋巴瘤生长，表明淋巴瘤的内在变化导致了加速生长。在小鼠体内生长而不消耗NK细胞的能力似乎并不伴随NK细胞识别淋巴瘤的变化。相反，淋巴瘤免疫与NK细胞数量的减少有关：所有小鼠在免疫后三到八周开始出现白血病期，随后NK细胞从血液中消失。我们还观察到死亡时脾脏中的NK细胞数量显著减少。联合培养实验表明，当免疫后淋巴瘤细胞以不需要直接接触细胞的机制存在时，NK细胞对IL-15的反应增殖能力降低。这些数据共同表明，TCR参与导致T细胞淋巴瘤细胞的内在变化，导致体内生长加速和导致NK细胞消失的因子分泌加快。

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  • 来源
    《Cellular immunology》 |2020年第1期|共8页
  • 作者

    Dubois Sigrid; Waldmann Thomas A.; Muller Jurgen R.;

  • 作者单位

    NCI Lymphoid Malignancies Branch Ctr Canc Res NIH Bethesda MD 20892 USA;

    NCI Lymphoid Malignancies Branch Ctr Canc Res NIH Bethesda MD 20892 USA;

    NCI Lymphoid Malignancies Branch Ctr Canc Res NIH Bethesda MD 20892 USA;

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  • 正文语种 eng
  • 中图分类 细胞生物学;
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