Identification of H7N9 hemagglutinin novel protein epitopes that elicit strong antibody-dependent, cell-mediated cytotoxic activities with protection from influenza infection in mouse model

Zhu Peipei; Yi Xianghua; Zhang Long; Liu Yuting; Wang Siqi; Gu Jun; Zhu Xuyou; Yu Xiaoting

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Identification of H7N9 hemagglutinin novel protein epitopes that elicit strong antibody-dependent, cell-mediated cytotoxic activities with protection from influenza infection in mouse model

机译：H7N9血凝素新蛋白表位的鉴定，引发强抗体依赖性，细胞介导的细胞毒性活性与小鼠模型中的流感感染保护

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Background: Antibody-dependent cell-mediated cytotoxicity (ADCC) is one of the mechanisms connecting humoral immunity and cellular immunity and has been well-demonstrated in recent studies. Neutralizing antibodies and antibodies can mediate ADCC effects and both build a strong defense against H7N9 influenza virus infection. In our previous study, we found that H7N9 patients' plasma displayed low neutralizing activities that were not sufficient for host protection; however, the plasma of some patients can mediate strong ADCC effects.

机译：背景：抗体依赖性细胞介导的细胞毒性（ADCC）是连接体液免疫和细胞免疫的机制之一，在最近的研究中得到了很好的证明。中和抗体和抗体可介导ADCC效应，并对H7N9流感病毒感染建立强有力的防御。在我们之前的研究中，我们发现H7N9患者血浆的中和活性较低，不足以保护宿主；然而，一些患者的血浆可以介导强烈的ADCC效应。

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来源
《Cellular immunology》 |2021年第1期|共8页
作者
Zhu Peipei; Yi Xianghua; Zhang Long; Liu Yuting; Wang Siqi; Gu Jun; Zhu Xuyou; Yu Xiaoting;
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作者单位

Tongji Univ Sch Med Tongji Hosp Dept Pathol Shanghai 200065 Peoples R China;

Tongji Univ Sch Med Tongji Hosp Dept Pathol Shanghai 200065 Peoples R China;

Tongji Univ Sch Med Tongji Hosp Dept Pathol Shanghai 200065 Peoples R China;

Tongji Univ Sch Med Tongji Hosp Dept Pathol Shanghai 200065 Peoples R China;

Tongji Univ Sch Med Tongji Hosp Dept Pathol Shanghai 200065 Peoples R China;

Tongji Univ Sch Med Tongji Hosp Dept Pathol Shanghai 200065 Peoples R China;

Tongji Univ Sch Med Tongji Hosp Dept Pathol Shanghai 200065 Peoples R China;

Tongji Univ Sch Med Tongji Hosp Dept Pathol Shanghai 200065 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Vaccine; ADCC; H7N9; Epitope; Library;

机译：疫苗;ADCC;H7N9;表位;图书馆;

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专利

1. Identification of a CD4 T-cell epitope in the hemagglutinin stalk domain of pandemic H1N1 influenza virus and its antigen-driven TCR usage signature in BALB/c mice [J] . I-Na Lu, Sophie Farinelle, Aurélie Sausy, 中国免疫学杂志（英文版） . 2017,第006期
2. Identification of a CD4 T-cell epitope in the hemagglutinin stalk domain of pandemic H 1N 1 influenza virus and its antigen-driven TCR usage signature in BALB/c mice [J] . I-Na Lu, Sophie Farinelle, Aurelie Sausy, 细胞与分子免疫学：英文版 . 2017,第006期
3. Identification of a Novel Universal Potential Epitope on the Cytoplasmic Tail of H7N9 Virus Hemagglutinin [J] . Xi Liu1, Li Ding1, Jing Yuan3, 中国病毒学：英文版 . 2019,第003期
4. Antibody-Dependent Cell-Mediated Cytotoxicity to Hemagglutinin of Influenza A Viruses After Influenza Vaccination in Humans [J] . Weimin Zhong, Jason R. Wilson, Yaohui Bai, Open Forum Infectious Diseases . 2016,第2期

机译：在人中接种流感疫苗后，抗体依赖性细胞介导的对甲型流感病毒血凝素的细胞毒性
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机译：表达H7N9禽流感病毒H7N9血血糖素的重组杆状病毒疫苗赋予鸡的致死高度致病H7N9病毒感染全面保护
6. Vaccine based on antibody-dependent cell-mediated cytotoxicity epitope on the H1N1 influenza virus increases mortality in vaccinated mice [J] . Jiqin Wang, Mei Liu, Nianchang Ding, Biochemical and Biophysical Research Communications . 2018,第3期

机译：基于抗体依赖性细胞介导的细胞毒性表位对H1N1流感病毒的疫苗增加了疫苗的小鼠中的死亡率
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机译：用人和小鼠基因组序列信息鉴定小鼠异种移植模型的旋转蛋白结合蛋白
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机译：一种新型的人性化小鼠模型，用于研究HIV感染和抗逆转录病毒疗法以及人类造血干细胞传递的基因疗法，以产生抗HIV细胞毒性T细胞。
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机译：大流行H1N1流感病毒血凝素抗原的主要抗体依赖性细胞介导的细胞毒性表位的鉴定
10. Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice [O] . Zi-Wei Ye, Shuofeng Yuan, Kwok-Man Poon, 2017

机译：大流行性H1N1流感病毒血凝素头部区域的抗体依赖性细胞介导的细胞毒性表位在H1N1感染小鼠中发挥有害作用
11. Mouse Model for Aerosol Infection of Influenza (Postprint). [R] . McDonald, R. S., Heimbuch, B. K., Sambol, A. R., 2011

机译：流感病毒气雾剂感染的小鼠模型（postprint）。

Identification of H7N9 hemagglutinin novel protein epitopes that elicit strong antibody-dependent, cell-mediated cytotoxic activities with protection from influenza infection in mouse model

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