Causal link between immunoglobulin G glycosylation and cancer: A potential glycobiomarker for early tumor detection

Wang Junyan; Huang Chuncui; Zhou Jinyu; Zhao Keli; Li Yan

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Causal link between immunoglobulin G glycosylation and cancer: A potential glycobiomarker for early tumor detection

机译：免疫球蛋白G糖基化与癌症的因果关系：早期肿瘤检测的潜在糖蛋白

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Changes in immunoglobulin G (IgG) glycan structures are currently believed to closely related to the emergence of cancer. In this review, we summarize the current body of evidence suggesting that differences in serum IgG glycosylation patterns correspond to changes in multiple types of cancer. Modifications include IgG terminal N-link galactosylation, IgG core fucosylation, IgG terminal sialylation, and IgG terminal bisecting N-acetylglucosamine. IgG N-glycomic alterations represent promising novel biomarkers for non-invasive-cancer diagnosis, prognosis, and progression monitoring; they are characterized by high sensitivity and specificity, compensating for previously identified glycobiomarkers.

机译：目前认为，免疫球蛋白G（IgG）聚糖结构的变化与癌症的发生密切相关。在这篇综述中，我们总结了目前的大量证据，表明血清IgG糖基化模式的差异对应于多种癌症的变化。修饰包括IgG末端N-链半乳糖基化、IgG核心岩藻糖基化、IgG末端唾液酸化和IgG末端对分N-乙酰氨基葡萄糖。IgG N-糖基组学改变代表了非侵袭性癌症诊断、预后和进展监测的有前途的新生物标志物；它们的特点是高度的敏感性和特异性，弥补了以前发现的糖类生物标记物。

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来源
《Cellular immunology》 |2021年第1期|共9页
作者
Wang Junyan; Huang Chuncui; Zhou Jinyu; Zhao Keli; Li Yan;
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作者单位

Chinese Acad Sci Inst Biophys Key Lab Interdisciplinary Res Beijing 100101 Peoples R China;

Chinese Acad Sci Inst Biophys Key Lab Interdisciplinary Res Beijing 100101 Peoples R China;

Chinese Acad Sci Inst Biophys Key Lab Interdisciplinary Res Beijing 100101 Peoples R China;

Chinese Acad Sci Inst Biophys Key Lab Interdisciplinary Res Beijing 100101 Peoples R China;

Chinese Acad Sci Inst Biophys Key Lab Interdisciplinary Res Beijing 100101 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
IgG glycosylation; Cancer; Biomarkers;

机译：IgG糖基化;癌症;生物标志物;

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1. Acquired potential N-glycosylation sites within the tumor-specific immunoglobulin heavy chains of B-cell malignancies | Haematologica [J] . N Zabalegui, AL de Cerio, S Inoges, Haematologica . 2004,第5期

机译：B细胞恶性肿瘤的肿瘤特异性免疫球蛋白重链中潜在的N-糖基化位点|血液学
2. Identifying causal networks linking cancer processes and anti-tumor immunity using Bayesian network inference and metagene constructs [J] . Kaiser Jacob L., Bland Cassidy L., Klinke David J. II Biotechnology Progress . 2016,第2期

机译：使用贝叶斯网络推论和元基因构建物鉴定联系癌症过程和抗肿瘤免疫力的因果网络
3. Change in IgG1 Fc N-linked glycosylation in human lung cancer: Age- and sex-related diagnostic potential [J] . ChenG., WangY., QinX., Electrophoresis: The Official Journal of the International Electrophoresis Society . 2013,第16期

机译：人肺癌中IgG1 Fc N-联糖基化的变化：与年龄和性别相关的诊断潜力
4. SOMATIC MUTATIONS CREATE POTENTIAL N-GLYCOSYLATION SITES IN THE IMMUNOGLOBULIN LIGHT CHAIN VARIABLE REGIONS IN PRIMARY AMYLOIDOSIS [C] . T. Prokaeva, B Spencer, G Doros, International Symposium on Amyloidosis . 2008

机译：体细胞突变在原发性淀粉样蛋白病中产生免疫球蛋白轻链可变区中的潜在的N-糖基化位点
5. Near-Infrared Silica-Based Gold Nanoshells as Potential Rapid Diagnostic Imaging Agents for Breast Cancer Tumor Detection [D] . Bickford, Lissett Ramirez 2010

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6. Removal of N-Linked Glycosylation Enhances PD-L1 Detection in Colon Cancer: Validation Research Based on Immunohistochemistry Analysis [O] . Junying Xu, Xuejing Yang, Yong Mao, 2021

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7. Investigating breast cancer O-linked glycosylation changes and their immunotherapeutic potential [O] . Picco Gianfranco 2013

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8. Development of a Novel Prognostic Marker to Link a Potential Tumor Suppressor Gene at Chromosome 6q to Aberrant Signal Transduction Pathway in Breast Cancer [R] . Zheng, P. 2005

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Causal link between immunoglobulin G glycosylation and cancer: A potential glycobiomarker for early tumor detection

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