Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury

Zhao Xinhao; Yang Le; Chang Na; Hou Lei; Zhou Xuan; Dong Chengbin; Liu Fuquan; Yang Lin; Li Liying

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Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury

机译：中性粒细胞募集在慢性肝损伤期间由鞘氨醇1-磷酸（S1P）/ S1P受体介导的

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Excessive neutrophils are recruited to damaged tissue and cause collateral injury under chronic inflammatory conditions. Sphingosine 1-phosphate (S1P) modulates kinds of physiological and pathological actions by inducing recruitment of various cell types through S1P receptors (S1PRs). This study aimed to detect the S1P/S1PRs-mediated effects on neutrophil recruitment during chronic liver inflammation. In present study, increased neutrophils originated from bone marrow (BM) were detected in liver tissue of BDL-treated mice. Hepatic sphingosine kinase 1 (SphK, S1P rate-limiting enzyme) or S1P levels positively correlated with neutrophil marker expression in liver of mice and patients. In vitro, expression of S1PR(1), S1PR(2) and S1PR(3) were detected in both mouse BM neutrophils and differentiated human neutrophil-like (dHL60) cells. S1P powerfully boosted the migration and cytoskeletal remodeling of BM neutrophils through S1PR(1) or S1PR(2). Different from BM neutrophils, the migration and cytoskeletal remodeling of dHL60 cells were mediated by S1PR(2) or S1PR(3). S1PR(2) blockade obviously attenuates neutrophil infiltration in bile duct ligation (BDL)-induced mouse liver injury. In conclusion, S1P/S1PRs system plays a pivotal role in neutrophil recruitment.

机译：在慢性炎症条件下，过多的中性粒细胞被吸收到受损组织中，并导致侧枝损伤。1-磷酸鞘氨醇（S1P）通过S1P受体（S1PRs）诱导不同类型的细胞募集，从而调节各种生理和病理行为。本研究旨在检测慢性肝脏炎症期间S1P/S1PRs介导的中性粒细胞募集效应。在本研究中，在BDL治疗的小鼠肝组织中检测到来自骨髓（BM）的中性粒细胞增多。肝鞘氨醇激酶1（SphK，S1P限速酶）或S1P水平与小鼠和患者肝脏中性粒细胞标志物表达呈正相关。在体外，在小鼠BM中性粒细胞和分化的人中性粒细胞样细胞（dHL60）中检测到S1PR（1）、S1PR（2）和S1PR（3）的表达。S1P通过S1PR（1）或S1PR（2）有力地促进了BM中性粒细胞的迁移和细胞骨架重塑。与BM中性粒细胞不同，dHL60细胞的迁移和细胞骨架重塑是由S1PR（2）或S1PR（3）介导的。S1PR（2）阻断可明显减轻胆管结扎（BDL）诱导的小鼠肝损伤中的中性粒细胞浸润。总之，S1P/S1PRs系统在中性粒细胞募集中起着关键作用。

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来源
《Cellular immunology》 |2021年第1期|共11页
作者
Zhao Xinhao; Yang Le; Chang Na; Hou Lei; Zhou Xuan; Dong Chengbin; Liu Fuquan; Yang Lin; Li Liying;
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作者单位

Capital Med Univ Dept Cell Biol Municipal Lab Liver Protect &

Regulat Regenerat Beijing 100069;

Capital Med Univ Dept Cell Biol Municipal Lab Liver Protect &

Regulat Regenerat Beijing 100069;

Capital Med Univ Dept Cell Biol Municipal Lab Liver Protect &

Regulat Regenerat Beijing 100069;

Capital Med Univ Dept Cell Biol Municipal Lab Liver Protect &

Regulat Regenerat Beijing 100069;

Capital Med Univ Dept Cell Biol Municipal Lab Liver Protect &

Regulat Regenerat Beijing 100069;

Capital Med Univ Beijing Shijitan Hosp Dept Intervent Therapy Beijing Peoples R China;

Capital Med Univ Beijing Shijitan Hosp Dept Intervent Therapy Beijing Peoples R China;

Capital Med Univ Dept Cell Biol Municipal Lab Liver Protect &

Regulat Regenerat Beijing 100069;

Capital Med Univ Dept Cell Biol Municipal Lab Liver Protect &

Regulat Regenerat Beijing 100069;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Neutrophil; Sphingosine 1-phosphate receptors; Recruitment; Liver Injury;

机译：中性粒细胞;鞘氨酸1-磷酸盐受体;招聘;肝损伤;

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1. Involvement of Sphingosine 1-Phosphate (S1P) Receptor Type 1 and Type 4 in Migratory Response of Mouse T Cells toward S1P [J] . Hirofumi Matsuyuki, Yasuhiro Maeda, Kazuhiro Yano, 中国免疫学杂志（英文版） . 2006,第006期
2. Involvement of Sphingosine 1-Phosphate （S1P） Receptor Type 1 and Type 4 in Migratory Response of Mouse T Cells toward S1P [J] . Hirofumi, Matsuyuki, Yasuhiro, 细胞与分子免疫学：英文版 . 2006,第006期
3. Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration [J] . Stephanie Mathews, Dechun Feng, Igor Maricic, 中国免疫学杂志（英文版） . 2016,第002期
4. Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3 [J] . Yasuhiro Maeda, Hirofumi Matsuyuki, Kyoko Shimano, The journal of immunology . 2007,第6期

机译：CD4 T细胞和树突状细胞向鞘氨醇1-磷酸（S1P）的迁移是由不同的受体亚型介导的：S1P通过3型S1P受体调节鼠成熟树突状细胞的功能。
5. Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3. [J] . Maeda Y, Matsuyuki H, Shimano K, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第6期

机译：CD4 T细胞和树突状细胞向1-磷酸鞘氨醇（S1P）的迁移是由不同的受体亚型介导的：S1P通过3型S1P受体调节鼠类成熟树突状细胞的功能。
6. Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis [J] . YangL., YueS., LiuX., Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2013,第1期

机译：鞘氨醇激酶/ 1-磷酸鞘氨醇（S1P）/ S1P受体轴参与肝纤维化相关的血管生成
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机译：S1P受体特异性药物通过调节局部炎症，增强新血管形成和增加祖细胞募集来增强下颌骨缺损的愈合
8. Regulation of sphingosine 1-phosphate (S1P) signaling for therapeutic arteriogenesis and tissue engineering. [D] . Sefcik, Lauren S. 2009

机译：调节鞘氨醇1-磷酸（S1P）信号，用于治疗性动脉生成和组织工程。
9. Sphingosine 1-Phosphate (S1P) Induced Interleukin-8 (IL-8) Release Is Mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS-2B Cells [O] . Michael J. O’Sullivan, Nobuaki Hirota, James G. Martin -1

机译：S1P受体2和核因子κB在BEAS-2B细胞中介导鞘氨醇1-磷酸（S1P）诱导的白介素8（IL-8）释放。
10. Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3 [O] . Yasuhiro Maeda, Hirofumi Matsuyuki, Kyoko Shimano, 2007

机译：CD4 T细胞和树突细胞朝向鞘氨醇1-磷酸（S1P）的迁移由不同的受体亚型介导：S1P通过S1P受体类型调节鼠成熟树突细胞的功能3
11. Effects of Chronic Alcohol Exposure on Kainate Receptor-Mediated Neurotransmission in the Hippocampus [R] . Valenzuela, C. F. 2004

机译：慢性酒精暴露对海马红藻氨酸受体介导的神经传递的影响

Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury

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