Improving pharmacological rescue of p53 function: RITA targets mutant p53.

Del Sal G

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Improving pharmacological rescue of p53 function: RITA targets mutant p53.

机译：改善P53功能的药理救助：RITA靶标突变体P53。

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Inactivation of the p53 pathway is observed in the majority of human tumors making this pathway attractive for therapeutic intervention. About 50 % of human tumors carry mutations in the p53 gene, and in tumors without p53 mutations its tumor suppressor function is often inactivated by alterations in other components of the pathway.

机译：在大多数人类肿瘤中观察到p53通路失活，这使得该通路对治疗干预具有吸引力。约50%的人类肿瘤携带p53基因突变，而在没有p53突变的肿瘤中，其抑癌功能往往因该途径其他成分的改变而失活。

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《Cell cycle》 |2010年第11期|共1页
作者
Del Sal G;
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University of Rosario Rosario Argentina.;

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正文语种 eng
中图分类细胞生物学;
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1. Effect of p53-targeted small molecular reactivator of p53 and induction of tumor apoptosis (RITA) combined with temozolomide (TMZ) on the glioma cell growth in vitro [J] . Tao Jiang, Qing Mao, Xiang Wang 海南医科大学学报（英文版） . 2017,第011期
2. Effect of p53-targeted small molecular reactivator of p53 and induction of tumor apoptosis (RITA) combined with temozolomide (TMZ) on the glioma cell growth in vitro [J] . Tao Jiang, Qing Mao, Xiang Wang 海南医科大学学报(英文版) . 2017,第011期
3. Improving pharmacological rescue of p53 function: RITA targets mutant p53. [J] . Del Sal G Cell cycle . 2010,第11期

机译：改善p53功能的药理挽救：RITA靶向突变体p53。
4. Improving pharmacological rescue of p53 function: RITA targets mutant p53. [J] . Del Sal G Cell cycle . 2010,第11期

机译：改善p53功能的药理挽救：RITA靶向突变体p53。
5. Improving pharmacological rescue of p53 function: RITA targets mutant p53. [J] . Del Sal G Cell cycle . 2010,第11期

机译：改善P53功能的药理救助：RITA靶标突变体P53。
6. Active learning framework of informative p53 cancer rescue mutants [C] . Haijin Wang, Ruhui Shen, Haichao Wang, International Conference on Advances in Electrical, Electronics, Information, Communication and Bio-Informatics . 2017

机译：信息丰富的p53癌症抢救突变体的主动学习框架
7. Crystal structures of oncogenic, suppressor and rescued p53 core domain mutants suggest the rescue mechanisms of global suppressor mutations [D] . Wang, Ying 2007

机译：致癌，抑制和挽救的p53核心域突变体的晶体结构表明了整体抑制突变的挽救机制
8. Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6 human mdm-2 and mutant p53. [O] . F Hoppe-Seyler, K Butz 1993

机译：人类乳头瘤病毒16型E6人类mdm-2和突变体p53在HeLa宫颈癌细胞中抑制内源性p53反式激活功能。
9. Pharmacological Targeting Of Mutant p53 Gain-of-Function Represses Mevalonate Pathway Of Cholesterol Biosynthesis And Sensitizes Tumor Cells To Radiation [O] . A. Nikolaev, D. Tong, C. Xing, 2020

机译：突变体P53的药理学靶向抑制胆固醇生物合成的甲戊二醇盐途径，并使肿瘤细胞敏感到辐射中
10. Structural Basis for the Pharmacological Rescue of Mutant p53 with Small Molecule Compounds. [R] . Ho, W. C. 2005

机译：用小分子化合物药理学拯救突变型p53的结构基础。

Improving pharmacological rescue of p53 function: RITA targets mutant p53.

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