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首页> 外文期刊>Cell cycle >Baseline cell proliferation rates and response to UV differ in lymphoblastoid cell lines derived from healthy individuals of extreme constitution types
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Baseline cell proliferation rates and response to UV differ in lymphoblastoid cell lines derived from healthy individuals of extreme constitution types

机译：基线细胞增殖率和对UV的反应在源自极端构造类型的健康个体中衍生的淋巴细胞细胞系不同

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Differences in human phenotypes and susceptibility to complex diseases are an outcome of genetic and environmental interactions. This is evident in diseases that progress through a common set of intermediate patho-endophenotypes. Precision medicine aims to delineate molecular players for individualized and early interventions. Functional studies of lymphoblastoid cell line (LCL) model of phenotypically well-characterized healthy individuals can help deconvolute and validate these molecular mechanisms. In this study, LCLs are developed from eight healthy individuals belonging to three extreme constitution types, deep phenotyped on the basis of Ayurveda. LCLs were characterized by karyotyping and immunophenotyping. Growth characteristics and response to UV were studied in these LCLs. Significant differences in cell proliferation rates were observed between the contrasting groups such that one type (Kapha) proliferates significantly slower than the other two (Vata, Pitta). In response to UV, one of the fast growing groups (Vata) shows higher cell death but recovers its numbers due to an inherent higher rates of proliferation. This study reveals that baseline differences in cell proliferation could be a key to understanding the survivability of cells under UV stress. Variability in baseline cellular phenotypes not only explains the cellular basis of different constitution types but can also help set priors during the design of an individualized therapy with DNA damaging agents. This is the first study of its kind that shows variability of intermediate patho-phenotypes among healthy individuals with potential implications in precision medicine.
机译：人类表型的差异和对复杂疾病的易感性是遗传和环境相互作用的结果。这在通过一组常见的中间病理内表型进展的疾病中很明显。精准医学旨在为个体化和早期干预描绘分子参与者。对具有良好表型特征的健康个体的淋巴母细胞系（LCL）模型进行功能研究，有助于反褶积和验证这些分子机制。在这项研究中，LCL是由八名健康个体发展而来的，他们属于三种极端体质类型，在阿育吠陀的基础上形成了深层表型。LCL的特征是核型和免疫表型。在这些LCL中研究了生长特性和对UV的响应。对比组之间的细胞增殖率存在显著差异，其中一种类型（Kapha）的增殖速度明显低于其他两种类型（Vata、Pitta）。作为对紫外线的反应，其中一个快速生长组（Vata）显示出较高的细胞死亡，但由于固有的较高增殖率，其数量恢复。这项研究表明，细胞增殖的基线差异可能是理解细胞在紫外线胁迫下生存能力的关键。基线细胞表型的变异性不仅可以解释不同体质类型的细胞基础，还可以帮助确定使用DNA损伤剂进行个体化治疗的优先顺序。这是同类研究中首次显示健康个体中间病理表型的变异性，对精确医学具有潜在意义。

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