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首页> 外文期刊>Biological trace element research >Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial
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Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

机译：镁 - 锌 - 钙 - 维生素D共同补充改善了荷尔蒙型曲线，炎症和具有多囊卵巢综合征的女性炎症和氧化胁迫的生物标志物：随机，双盲，安慰剂对照试验

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Data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on hormonal profiles, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS) are scarce. The objective of this study was to assess the effects of magnesium-zinc-calcium-vitamin D co-supplementation on hormonal profiles, biomarkers of inflammation, and oxidative stress in women with PCOS. Sixty PCOS women were randomized into two groups and treated with 100 mg magnesium, 4 mg zinc, 400 mg calcium plus 200 IU vitamin D supplements (n = 30), or placebo (n = 30) twice a day for 12 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were assessed at baseline and at end-of-treatment. After the 12-week intervention, compared with the placebo, magnesium-zinc-calcium-vitamin D co-supplementation resulted in significant reductions in hirsutism (-2.4 +/- 1.2 vs. -0.1 +/- 0.4, P 0.001), serum high sensitivity C-reactive protein (-0.7 +/- 0.8 vs. +0.2 +/- 1.8 mg/L, P 0.001), and plasma malondialdehyde (-0.4 +/- 0.3 vs. +0.2 +/- 1.0 mu mol/L, P = 0.01), and a significant increase in plasma total antioxidant capacity concentrations (+46.6 +/- 66.5 vs. -7.7 +/- 130.1 mmol/L, P = 0.04). We failed to find any significant effect of magnesium-zinc-calcium-vitamin D co-supplementation on free androgen index, and other biomarkers of inflammation and oxidative stress. Overall, magnesium-zinc-calcium-vitamin D co-supplementation for 12 weeks among PCOS women had beneficial effects on hormonal profiles, biomarkers of inflammation, and oxidative stress.
机译：关于多囊卵巢综合征（PCOS）妇女补充镁锌钙维生素D对激素水平、炎症生物标志物和氧化应激的影响的数据很少。本研究的目的是评估镁-锌-钙-维生素D复合补充剂对多囊卵巢综合征（PCOS）患者激素水平、炎症生物标志物和氧化应激的影响。60名多囊卵巢综合征妇女被随机分为两组，分别服用100毫克镁、4毫克锌、400毫克钙和200 IU维生素D补充剂（n=30）或安慰剂（n=30），每天两次，共12周。在基线检查和治疗结束时评估激素水平、炎症生物标志物和氧化应激。在12周的干预后，与安慰剂相比，镁-锌-钙-维生素D复合补充剂显著降低了多毛症（-2.4+/-1.2 vs.-0.1+/-0.4，P；0.001）、血清高敏C反应蛋白（-0.7+/-0.8 vs.+0.2+/-1.8 mg/L，P；0.001）和血浆丙二醛（-0.4+/-0.3 vs.+0.2+/-1.0μmol/L，P=0.01），血浆总抗氧化能力浓度显著增加（+46.6+/-66.5 vs.-7.7+/-130.1 mmol/L，P=0.04）。我们没有发现补充镁锌钙维生素D对游离雄激素指数以及炎症和氧化应激的其他生物标志物有任何显著影响。总体而言，PCOS妇女12周的镁锌钙维生素D联合补充对激素水平、炎症生物标志物和氧化应激有有益影响。

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