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Multifaceted control of mRNA translation machinery in cancer

机译：癌症MRNA翻译机械的多方录

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The mRNA translation machinery is tightly regulated through several, at times overlapping, mechanisms that modulate its efficiency and accuracy. Due to their fast rate of growth and metabolism, cancer cells require an excessive amount of mRNA translation and protein synthesis. However, unfavorable conditions, such as hypoxia, amino acid starvation, and oxidative stress, which are abundant in cancer, as well as many anti-cancer treatments inhibit mRNA translation. Cancer cells adapt to the various internal and environmental stresses by employing specialised transcript-specific translation to survive and gain a proliferative advantage. We will highlight the major signaling pathways and mechanisms of translation that regulate the global or mRNA-specific translation in response to the intra- or extra-cellular signals and stresses that are key components in the process of tumourigenesis.
机译：mRNA翻译机制通过几个有时重叠的机制进行严格调控，这些机制调节其效率和准确性。由于其生长和代谢速度快，癌细胞需要过量的mRNA翻译和蛋白质合成。然而，诸如缺氧、氨基酸饥饿和氧化应激等不利条件（在癌症中大量存在）以及许多抗癌治疗都会抑制mRNA翻译。癌细胞通过使用专门的转录特异性翻译来适应各种内部和环境压力，从而生存并获得增殖优势。我们将重点介绍主要的信号通路和翻译机制，它们调节整体或mRNA特异性翻译，以响应细胞内或细胞外信号和应激，这些信号和应激是肿瘤发生过程中的关键组成部分。

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