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首页> 外文期刊>Cellular and molecular life sciences: CMLS >Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses
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Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses

机译：通过对SARS-COV-2，人SARS和BAT SARS的黑暗蛋白质蛋白质蛋白质的比较分析来了解Covid-19

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The recently emerged coronavirus designated as SARS-CoV-2 (also known as 2019 novel coronavirus (2019-nCoV) or Wuhan coronavirus) is a causative agent of coronavirus disease 2019 (COVID-19), which is rapidly spreading throughout the world now. More than 1.21 million cases of SARS-CoV-2 infection and more than 67,000 COVID-19-associated mortalities have been reported worldwide till the writing of this article, and these numbers are increasing every passing hour. The World Health Organization (WHO) has declared the SARS-CoV-2 spread as a global public health emergency and admitted COVID-19 as a pandemic now. Multiple sequence alignment data correlated with the already published reports on SARS-CoV-2 evolution indicated that this virus is closely related to the bat severe acute respiratory syndrome-like coronavirus (bat SARS-like CoV) and the well-studied human SARS coronavirus (SARS-CoV). The disordered regions in viral proteins are associated with the viral infectivity and pathogenicity. Therefore, in this study, we have exploited a set of complementary computational approaches to examine the dark proteomes of SARS-CoV-2, bat SARS-like, and human SARS CoVs by analysing the prevalence of intrinsic disorder in their proteins. According to our findings, SARS-CoV-2 proteome contains very significant levels of structural order. In fact, except for nucleocapsid, Nsp8, and ORF6, the vast majority of SARS-CoV-2 proteins are mostly ordered proteins containing less intrinsically disordered protein regions (IDPRs). However, IDPRs found in SARS-CoV-2 proteins are functionally important. For example, cleavage sites in its replicase 1ab polyprotein are found to be highly disordered, and almost all SARS-CoV-2 proteins contains molecular recognition features (MoRFs), which are intrinsic disorder-based protein-protein interaction sites that are commonly utilized by proteins for interaction with specific partners. The results of our extensive investigation of the dark side of SARS-CoV-2 proteome will have important implications in understanding the structural and non-structural biology of SARS or SARS-like coronaviruses.
机译：新型冠状病毒2019冠状病毒疾病（SARS）是一种冠状病毒病的病原体（COVID-19），目前已在世界范围内迅速传播。武汉冠状病毒（SARS）是一种冠状病毒（COVID-19）的病原体。在撰写本文之前，全球已报告超过121万例SARS-CoV-2感染病例和超过6.7万例CoV-19相关死亡病例，而且这些数字每小时都在增加。急诊科宣布全球艾滋病2019冠状病毒疾病传播，并承认COVID-19是一种流行病。与已发表的SARS-CoV-2进化报告相关的多序列比对数据表明，该病毒与蝙蝠严重急性呼吸综合征样冠状病毒（蝙蝠SARS样冠状病毒）和研究充分的人类SARS冠状病毒（SARS-CoV）密切相关。病毒蛋白质中的无序区域与病毒的传染性和致病性有关。因此，在这项研究中，我们利用了一套互补的计算方法，通过分析SARS-CoV-2、蝙蝠SARS样和人类SARS-CoV蛋白质中内在疾病的患病率，来研究它们的暗蛋白质组。根据我们的发现，SARS-CoV-2蛋白质组包含非常重要的结构顺序。事实上，除了核衣壳蛋白、Nsp8和ORF6外，绝大多数SARS-CoV-2蛋白质大多是含有较少内在无序蛋白质区（IDPR）的有序蛋白质。然而，在SARS-CoV-2蛋白中发现的IDPR在功能上很重要。例如，发现其复制酶1ab多蛋白中的裂解位点高度无序，几乎所有SARS-CoV-2蛋白质都包含分子识别特征（MORF），这是蛋白质通常用于与特定伙伴相互作用的基于内在无序的蛋白质-蛋白质相互作用位点。我们对SARS-CoV-2蛋白质组黑暗面的广泛研究结果将对理解SARS或SARS样冠状病毒的结构和非结构生物学具有重要意义。

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